Title:
P2X4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2015/005468
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by general formula (II) having a P2X4 receptor antagonist action.
(II)
(In the formula, R1a to R6a are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, etc., Xa is C or N, and Ya is N or C (=O), provided that when Xa is C, Ya is N, and when Xa is N, Ya is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, Aa is a benzene ring, a pyridine ring, etc., Da is a tetrazole ring, an imidazole ring, etc., Ea is -(CR9aR10a)p-Ta-, and Ga is a benzene ring, a pyridine ring, etc.)
Inventors:
SAKUMA SHOGO (JP)
KOBAYASHI KUNIO (JP)
USHIODA MASATOSHI (JP)
SAITO DAISUKE (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
KOBAYASHI KUNIO (JP)
USHIODA MASATOSHI (JP)
SAITO DAISUKE (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
Application Number:
PCT/JP2014/068541
Publication Date:
January 15, 2015
Filing Date:
July 11, 2014
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
UNIV KYUSHU (JP)
UNIV KYUSHU (JP)
International Classes:
C07D403/10; A61K31/551; A61P25/04; A61P43/00; C07D401/04; C07D403/08
Domestic Patent References:
| WO2012014910A1 | 2012-02-02 | |||
| WO2010093061A1 | 2010-08-19 | |||
| WO2012011549A1 | 2012-01-26 | |||
| WO2012060397A1 | 2012-05-10 | |||
| WO2012161301A1 | 2012-11-29 | |||
| WO2012008478A1 | 2012-01-19 | |||
| WO2004085440A1 | 2004-10-07 | |||
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| WO2012011549A1 | 2012-01-26 | |||
| WO2012014910A1 | 2012-02-02 | |||
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Foreign References:
| US20050074819A1 | 2005-04-07 |
Other References:
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TOZAKI-SAITOH H; TSUDA M.; MIYATA H.; UEDA K.; KOHSAKA S.; INOUE K.: "P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury", NEUROSCIENCE, vol. 28, no. 19, 2008, pages 4949 - 4956
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SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
M. TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
THE 49TH CONVENTION OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, 2006
J. AM. CHEM. SOC., vol. 134, 2012, pages 9796
HETEROCYCLES, vol. 76, 2008, pages 507
TOZAKI-SAITOH H; TSUDA M.; MIYATA H.; UEDA K.; KOHSAKA S.; INOUE K.: "P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury", NEUROSCIENCE, vol. 28, no. 19, 2008, pages 4949 - 4956
CHAPLAN SR; BACH FW; POGREL JW; CHUNG JM; YAKSH TL: "Quantitative assessment of tactile allodynia in the rat paw", J. NEUROSCI. METHOD, vol. 53, 1994, pages 55 - 63, XP024352718, DOI: doi:10.1016/0165-0270(94)90144-9
Attorney, Agent or Firm:
CHIGUSA, Shinichi et al. (JP)
1000 Shin-ichi Kusa (JP)
1000 Shin-ichi Kusa (JP)
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