Title:
P70-S6K or related kinase with constitutive activity
Document Type and Number:
WIPO Patent Application WO1998018935
Kind Code:
A3
Inventors:
THOMAS GEORGE (FR)
KOZMA SARA (FR)
KOZMA SARA (FR)
Application Number:
PCT/EP1997/005979
Publication Date:
July 30, 1998
Filing Date:
October 29, 1997
Export Citation:
Assignee:
NOVARTIS AG (FR)
THOMAS GEORGE (FR)
KOZMA SARA (FR)
THOMAS GEORGE (FR)
KOZMA SARA (FR)
International Classes:
C12N9/12; C12N15/54; (IPC1-7): C12N15/54; C12N9/12; G01N33/573
Domestic Patent References:
| WO1993019752A1 | 1993-10-14 |
Other References:
PEARSON R B ET AL: "THE PRINCIPAL TARGET OF RAPAMYCIN-INDUCED P70S6K INACTIVATION IS A NOVEL PHOSPHORYLATION SITE WITHIN A CONSERVED HYDROPHOBIC DOMAIN", EMBO JOURNAL, vol. 14, no. 21, 1 November 1995 (1995-11-01), pages 5279 - 5287, XP000561164
PROUD C. G.: "p70 S6 kinase: an enigma with variations.", TRENDS IN BIOCHEMICAL SCIENCES, vol. 21, no. 5, May 1996 (1996-05-01), pages 181 - 185, XP002057556
HAN J.W. ET AL.: "Rapamycin, Wortmannin, and the methylxanthine SQ200006 inactivate p70-S6K by inducing dephosphorylation of the same subset of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 36, 1995, pages 21396 - 21403, XP002057557
FERRARI S. ET AL.: "The immunosuppressant rapamycin induces inactivation of p70-S6K through dephosphorylation of a novel set of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 22, 1993, pages 16091 - 16094, XP002057558
DENNIS P. B. ET AL.: "The principal rapamycin-sensitive p70-S6K phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 11, November 1996 (1996-11-01), pages 6242 - 6251, XP002057559
PROUD C. G.: "p70 S6 kinase: an enigma with variations.", TRENDS IN BIOCHEMICAL SCIENCES, vol. 21, no. 5, May 1996 (1996-05-01), pages 181 - 185, XP002057556
HAN J.W. ET AL.: "Rapamycin, Wortmannin, and the methylxanthine SQ200006 inactivate p70-S6K by inducing dephosphorylation of the same subset of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 36, 1995, pages 21396 - 21403, XP002057557
FERRARI S. ET AL.: "The immunosuppressant rapamycin induces inactivation of p70-S6K through dephosphorylation of a novel set of sites.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 22, 1993, pages 16091 - 16094, XP002057558
DENNIS P. B. ET AL.: "The principal rapamycin-sensitive p70-S6K phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.", MOLECULAR AND CELLULAR BIOLOGY, vol. 16, no. 11, November 1996 (1996-11-01), pages 6242 - 6251, XP002057559
Download PDF: