Title:
PARTIAL AGONIST SPECIFIC TO LXR&agr RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2005/092323
Kind Code:
A1
Abstract:
It is intended to provide a compound which is useful in preventing and treating arteriosclerosis-related diseases because of binding to a receptor as a ligand specific to human liver X receptor &agr (LXR&agr ), i.e., a nuclear receptor, to thereby promote the HDL production in peripheral cells. Namely, a medicinal composition for preventing or treating LXR&agr -related diseases which contains an LXR&agr -selective agonist such as a cyclic bisbenzil compound represented by the following general formula (1), its pharmaceutically acceptable salt or a hydrate thereof. (1) wherein R1, R2 and R3 independently represent each a group selected form among hydrogen, acyl, alkyl and aryl groups, provided that the case where R1 is a methyl group and R2 and R3 are hydrogen atoms is excluded.
Inventors:
INOUE KAZUHIDE (JP)
MOGAMI TOMOKO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
TAMEHIRO NORIMASA (JP)
MOGAMI TOMOKO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
TAMEHIRO NORIMASA (JP)
Application Number:
PCT/JP2005/005142
Publication Date:
October 06, 2005
Filing Date:
March 22, 2005
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND (JP)
INOUE KAZUHIDE (JP)
MOGAMI TOMOKO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
TAMEHIRO NORIMASA (JP)
INOUE KAZUHIDE (JP)
MOGAMI TOMOKO (JP)
ASAKAWA YOSHINORI (JP)
HASHIMOTO TOSHIHIRO (JP)
TAMEHIRO NORIMASA (JP)
International Classes:
A61K31/335; A61P9/10; C07D313/00; (IPC1-7): A61K31/335; A61P9/10; C07D313/00
Foreign References:
| JPS58208286A | 1983-12-03 |
Other References:
SCHWARTNER C. ET AL: "Effect of marchantins and related compounds on 5-lipoxygenase and cyclooxygenase and their antioxidant properties: a structure activity relationship study.", PHYTOMEDICINE., vol. 2, no. 2, 1995, pages 113 - 117, XP002989421
EICHER T. ET AL: "Synthesis of cyclic bis-bibenzyl systems.", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY., no. 5, 1998, pages 877 - 888, XP001056010
ASAKAWA Y. ET AL: "Riccardin A and riccardin B, two novel cyclic bis(bibenzyls) possesing cytotoxicity from the liverwort Riccardia multifida(L) S. Gray.", JOURNAL OF ORGANIC CHEMISTRY., vol. 48, no. 13, 1983, pages 2164 - 2167, XP002990145
YOSHIDA T. ET AL: "Phenolic constituents of the liverwort: four novel cyclic bisbibenzyl dimers from Blasia pusilla L.", TETRAHEDRON., vol. 52, no. 46, 1996, pages 14487 - 14500, XP004105050
EICHER T. ET AL: "Synthesis of cyclic bis-bibenzyl systems.", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY., no. 5, 1998, pages 877 - 888, XP001056010
ASAKAWA Y. ET AL: "Riccardin A and riccardin B, two novel cyclic bis(bibenzyls) possesing cytotoxicity from the liverwort Riccardia multifida(L) S. Gray.", JOURNAL OF ORGANIC CHEMISTRY., vol. 48, no. 13, 1983, pages 2164 - 2167, XP002990145
YOSHIDA T. ET AL: "Phenolic constituents of the liverwort: four novel cyclic bisbibenzyl dimers from Blasia pusilla L.", TETRAHEDRON., vol. 52, no. 46, 1996, pages 14487 - 14500, XP004105050
Attorney, Agent or Firm:
Hiraki, Yusuke (3-20 Toranomon 4-chome, Minato-ku Tokyo 01, JP)
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