Title:
PHARMACEUTICAL COMPOSITION CONTAINING HMG-CoA REDUCTASE INHIBITOR AND GLUTATHIONE
Document Type and Number:
WIPO Patent Application WO/2006/033287
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a safe drug that simultaneously realizes (1) lowering of blood homocysteine level, (2) enhancement of the activity of nitrogen monoxide synthase of vascular endothelial cells and/or increase of blood nitrogen monoxide level ascribed to vascular endothelial cells and (3) enhancement of the activity of glutathione peroxidase. [MEANS FOR SOLVING PROBLEMS] There is provided a pharmaceutical composition comprising an HMG-CoA reductase inhibitor and glutathione.
Inventors:
TORIZUMI YASUHIRO
Application Number:
PCT/JP2005/017106
Publication Date:
March 30, 2006
Filing Date:
September 16, 2005
Export Citation:
Assignee:
SANKYO CO (JP)
TORIZUMI YASUHIRO
TORIZUMI YASUHIRO
International Classes:
A61K38/00; A61K31/22; A61K31/351; A61K31/366; A61K31/40; A61K31/404; A61K31/47; A61K31/505; A61K45/00; A61P3/10; A61P7/00; A61P7/02; A61P9/08; A61P9/10; A61P9/12; A61P15/00; A61P15/10; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D207/34; C07D209/18
Domestic Patent References:
| WO2004006919A1 | 2004-01-22 | |||
| WO2005046675A2 | 2005-05-26 |
Foreign References:
| JP2003511347A | 2003-03-25 | |||
| JP2001519388A | 2001-10-23 | |||
| JP2001523224A | 2001-11-20 | |||
| JP2004521083A | 2004-07-15 |
Other References:
RIDKER P.M. ET AL: "Plasma Homocysteine Concentration, Statin Therapy, and the Risk of First Acute Coronary Events.", CIRCULATION., vol. 105, 2002, pages 1776 - 1779, XP008036494
EGASHIRA KENSUKE.: "Domyakukoka no Hassho to Kekkan Naihi Saibo Kino.", JPN. PHARMACOL.THER. (PHARMACOLOGY & THERAPEUTICS), vol. 29, no. 10, 2001, pages 715 - 718, XP002997200
HAYASHI TOSHIO.: "Kandomyaku Kiken Inshi to Naihi Hogo Sayo.", KEKKAN IGAKU., vol. 2, no. 2, 2001, pages 189 - 194, XP002999668
KURUSU A. ET AL: "EFFECTS OF THE NEW HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR FLUVASTATIN ON ANTI-OXIDANT ENZYME ACTIVITIES AND RENAL FUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.", CLIN. EXP. PHARMACOL. PHYSIOL., vol. 27, 2000, pages 767 - 770, XP002999669
OCHI HIROSHI.: "Free Radical and Prostaglandin. (Kassei Sanso Free Radical)", J. ACT. OXYG. FREE RAD., vol. 6, no. 1, 1995, pages 38 - 45, XP002999670
EGASHIRA KENSUKE.: "Domyakukoka no Hassho to Kekkan Naihi Saibo Kino.", JPN. PHARMACOL.THER. (PHARMACOLOGY & THERAPEUTICS), vol. 29, no. 10, 2001, pages 715 - 718, XP002997200
HAYASHI TOSHIO.: "Kandomyaku Kiken Inshi to Naihi Hogo Sayo.", KEKKAN IGAKU., vol. 2, no. 2, 2001, pages 189 - 194, XP002999668
KURUSU A. ET AL: "EFFECTS OF THE NEW HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR FLUVASTATIN ON ANTI-OXIDANT ENZYME ACTIVITIES AND RENAL FUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.", CLIN. EXP. PHARMACOL. PHYSIOL., vol. 27, 2000, pages 767 - 770, XP002999669
OCHI HIROSHI.: "Free Radical and Prostaglandin. (Kassei Sanso Free Radical)", J. ACT. OXYG. FREE RAD., vol. 6, no. 1, 1995, pages 38 - 45, XP002999670
Attorney, Agent or Firm:
Yaguchi, Toshiaki c/o SANKYO COMPANY (LIMITED 2-58, Hiromachi 1-chome, Shinagawa-k, Tokyo 10, JP)
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