Title:
PIPERAZINE BASED INHIBITORS OF FACTOR Xa
Document Type and Number:
WIPO Patent Application WO2002026720
Kind Code:
A3
Abstract:
Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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Inventors:
ZHU BING-YAN (US)
JIA ZHAOZHONG JON (US)
ZHANG PENGLIE (US)
HUANG WENRONG (US)
WU YANHONG (US)
ZUCKETT JINGMEI FAN (US)
GOLDMAN ERIK A (US)
WANG LINGYAN (US)
SONG YONGHONG (US)
SCARBOROUGH ROBERT M (US)
JIA ZHAOZHONG JON (US)
ZHANG PENGLIE (US)
HUANG WENRONG (US)
WU YANHONG (US)
ZUCKETT JINGMEI FAN (US)
GOLDMAN ERIK A (US)
WANG LINGYAN (US)
SONG YONGHONG (US)
SCARBOROUGH ROBERT M (US)
Application Number:
PCT/US2001/030315
Publication Date:
October 31, 2002
Filing Date:
October 01, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
ZHU BING-YAN (US)
JIA ZHAOZHONG JON (US)
ZHANG PENGLIE (US)
HUANG WENRONG (US)
WU YANHONG (US)
ZUCKETT JINGMEI FAN (US)
GOLDMAN ERIK A (US)
WANG LINGYAN (US)
SONG YONGHONG (US)
SCARBOROUGH ROBERT M (US)
ZHU BING-YAN (US)
JIA ZHAOZHONG JON (US)
ZHANG PENGLIE (US)
HUANG WENRONG (US)
WU YANHONG (US)
ZUCKETT JINGMEI FAN (US)
GOLDMAN ERIK A (US)
WANG LINGYAN (US)
SONG YONGHONG (US)
SCARBOROUGH ROBERT M (US)
International Classes:
A61P7/02; C07D205/04; C07D209/30; C07D233/06; C07D239/06; C07D295/26; C07D333/62; C07D401/12; C07D403/12; C07D409/12; C07D409/14; (IPC1-7): C07D209/30; C07D403/12; C07D401/12; C07D333/62; C07D409/12; C07D295/22; C07D205/04; C07D233/06; C07D239/06; C07D409/14; A61K31/496; A61P7/02
Domestic Patent References:
| WO2000009480A1 | 2000-02-24 | |||
| WO1998054164A1 | 1998-12-03 |
Foreign References:
| EP1031563A1 | 2000-08-30 |
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