Title:
PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
Document Type and Number:
WIPO Patent Application WO1996001253
Kind Code:
A3
Abstract:
Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hypercholesterolemia and coronary artery disease.
Inventors:
HOMAN REYNOLD (US)
Application Number:
PCT/US1995/008167
Publication Date:
July 18, 1996
Filing Date:
June 28, 1995
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
International Classes:
A61K31/047; A61K31/05; A61K31/16; A61K31/195; A61K31/196; A61K31/215; A61K31/40; A61K31/41; A61K31/66; A61K45/00; A61P3/06; A61P9/10; A61P43/00; C07C15/16; C07C22/08; C07C25/18; C07C229/40; C07C229/44; C07C233/09; C07C255/28; C07C323/36; C07C323/63; C07D207/08; C07D257/04; C07F9/40; (IPC1-7): C07D207/08; A61K31/40
Domestic Patent References:
| WO1990012004A1 | 1990-10-18 | |||
| WO1994018167A1 | 1994-08-18 |
Foreign References:
| US4161529A | 1979-07-17 | |||
| EP0360685A1 | 1990-03-28 | |||
| US3573290A | 1971-03-30 | |||
| DE1923591A1 | 1969-11-13 | |||
| JPS5146103B1 | 1976-12-07 | |||
| EP0263229A1 | 1988-04-13 | |||
| EP0377896A2 | 1990-07-18 | |||
| EP0401857A2 | 1990-12-12 |
Other References:
DATABASE WPI Week 8836, Derwent World Patents Index; AN 88254447
DATABASE WPI Week 8836, Derwent World Patents Index; AN 88-254448
J. L. GROGAN, I. L. HONIGBERG: "Potential Hypocholesterolemic Agents: Dicinnamoyl Esters as Analogs of Cynarin", J. PHARM. SCI., vol. 61, no. 6, pages 802 - 803
DATABASE WPI Week 8836, Derwent World Patents Index; AN 88-254448
J. L. GROGAN, I. L. HONIGBERG: "Potential Hypocholesterolemic Agents: Dicinnamoyl Esters as Analogs of Cynarin", J. PHARM. SCI., vol. 61, no. 6, pages 802 - 803
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