PROCESS FOR PREPARING $g(b)-AMINO-$g(a)-HYDROXY ACID DERIVATIVES

Title:

PROCESS FOR PREPARING $g(b)-AMINO-$g(a)-HYDROXY ACID DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/007687

Kind Code:

A1

Abstract:

A process for preparing $g(b)-amino-$g(a)-hydroxy acid derivatives in an efficient and commercially useable manner. The process is characterized by hydrolyzing an $g(a)-amino-$g(a)',$g(a)'-dihaloketone derivative represented by general formula (1) in the presence of a base, optionally followed by the protection of the amino group, to prepare a $g(b)-amino-$g(a)-hydroxy acid derivative represented by general formula (2).

Inventors:

MATSUMOTO SHINGO (JP)
MATSUO KAZUHIKO (JP)
SUGAWA TADASHI (JP)
MOROSHIMA TADASHI (JP)
INOUE KENJI (JP)

Application Number:

PCT/JP1997/002844

Publication Date:

February 26, 1998

Filing Date:

August 18, 1997

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Assignee:

KANEKA CORP (JP)
MATSUMOTO SHINGO (JP)
MATSUO KAZUHIKO (JP)
SUGAWA TADASHI (JP)
MOROSHIMA TADASHI (JP)
INOUE KENJI (JP)

International Classes:

C07C227/02; C07C227/42; C07C229/22; C07C229/36; C07C269/08; C07C271/18; C07C271/22; C07C303/40; C07C303/44; C07C311/19; C07D209/26; C07C229/34; (IPC1-7): C07C229/22; C07C227/02; C07C229/34; C07D209/48

Domestic Patent References:

WO1997028105A1

1997-08-07

Other References:

TETRAHEDRON LETT., (1986), 27(14), KOLB, MICHAEL; BARTH, JACQUELINE; NEISES, BERNHARD, "Synthesis of Fluorinated .Alpha.-Amino Ketones. Part I: .Alpha.-Benzamidoalkyl Mono-,Di- and Trifluoromethyl Ketones", p. 1579-1582.
See also references of EP 0930292A4

Attorney, Agent or Firm:

Yasutomi, Yasuo (14-22 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka 532, JP)

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