PROCESS FOR PRODUCING 1,2-cis-2-FLUOROCYCLOPROPANE-1CARBOXYLIC ESTER COMPOUND

Title:

PROCESS FOR PRODUCING 1,2-cis-2-FLUOROCYCLOPROPANE-1CARBOXYLIC ESTER COMPOUND

Document Type and Number:

WIPO Patent Application WO/2005/095322

Kind Code:

A1

Abstract:

An industrially usable process for producing a 1,2-cis-2-fluorocyclopropane-1-carboxylic ester. The process, which is for producing a compound represented by the following general formula (3): [Chemical formula 2] (wherein R¹ represents C_1-8 alkyl, etc.), comprises reacting a compound represented by the following general formula (1): [Chemical formula 1] [wherein X¹ represents hydrogen, chlorine, bromine, or iodine and X² represents hydrogen, chlorine, bromine, or iodine, provided that not both of X¹ and X² are hydrogen; and R¹ is the same as defined above] with a reducing agent represented by the formula (2): M¹BH_mR²_n (2-1) or M²(BH_mR²_n)₂ (2-2) (wherein M¹ represents an alkali metal; M² represents an alkaline earth metal or zinc; R² represents hydrogen, etc.; and m is an integer of 1-4 and n is an integer of 0-3, provided that the sum of m and n is 4) in the presence of an aprotic polar solvent and a Lewis acid such as, e.g., a halide of an element selected among boron, magnesium, aluminum, etc.

Inventors:

SATO KOJI (JP)
IMAI MAKOTO (JP)

Application Number:

PCT/JP2005/006240

Publication Date:

October 13, 2005

Filing Date:

March 31, 2005

Export Citation:

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Assignee:

DAIICHI SEIYAKU CO (JP)
SATO KOJI (JP)
IMAI MAKOTO (JP)

International Classes:

C07C67/317; C07C69/74; C07B61/00; (IPC1-7): C07C67/317; C07C69/74

Domestic Patent References:

WO1995004712A1	1995-02-16
WO2004060851A1	2004-07-22

Foreign References:

JPH06157418A	1994-06-03
JPH0665140A	1994-03-08
EP0712831A1	1996-05-22

Other References: