PROCESS FOR PRODUCING 2',3'-DIDEOXY-beta-NUCLEOSIDE

Title:

PROCESS FOR PRODUCING 2',3'-DIDEOXY-beta-NUCLEOSIDE

Document Type and Number:

WIPO Patent Application WO/1992/022548

Kind Code:

A1

Abstract:

A process for producing a 2',3'-dideoxy-beta-nucleoside in a simplified manner in a high yield, which comprises condensing 1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-D-glycero-pentofuranose (IV), which is prepared from 5-(t-butyldiphenylsilyloxy)-2,2-di(phenylthio)-pentan-4-olide, with a pyrimidine derivative (V) in the presence of a Lewis acid catalyst, purifying the reaction product by chromatography into 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-beta-D-glycero-pentofuranosyl] pyrimidine (III), hydrodesulfurizing the pyrimidine (III) into 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-beta-D-glycero-pentofuranosyl] pyrimidine (II), and deblocking the pyrimidine (II) into 2',3'-dideoxy-beta-uridine (I) (wherein X represents oxygen and Y represents hydrogen).

Inventors:

KAWAKAMI HIROSHI (JP)
MATSUMOTO KATSUYA (JP)
KOSEKI KOSHI (JP)
EBATA TAKASHI (JP)

Application Number:

PCT/JP1992/000752

Publication Date:

December 23, 1992

Filing Date:

June 12, 1992

Export Citation:

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Assignee:

JAPAN TOBACCO INC (JP)

International Classes:

C07D405/04; C07F7/18; C07H19/06; (IPC1-7): C07D405/04

Foreign References:

JPH03215484A	1991-09-20
JPH0454193A	1992-02-21

Other References: