Title:
PROCESS FOR PRODUCING OPTICALLY ACTIVE $g(b)-AMINO KETONES, AND OPTICALLY ACTIVE BINUCLEAR PALLADIUM COMPLEX AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/1999/006352
Kind Code:
A1
Abstract:
A process for producing optically active $g(b)-amino ketones represented by general formula (III), characterized by reacting a silyl enol ether represented by general formula (I) with an imine represented by general formula (II) in the presence of a catalyst comprising palladium and optically active phosphine ligands; and a novel $g(m)-hydroxyl type binuclear palladium/optically active didentate phosphine complex (V).
Inventors:
SODEOKA MIKIKO (JP)
HAGIWARA EMIKO (JP)
FUJII AKIO (JP)
HAGIWARA EMIKO (JP)
FUJII AKIO (JP)
Application Number:
PCT/JP1998/003320
Publication Date:
February 11, 1999
Filing Date:
July 24, 1998
Export Citation:
Assignee:
SAGAMI CHEM RES (JP)
SODEOKA MIKIKO (JP)
HAGIWARA EMIKO (JP)
FUJII AKIO (JP)
SODEOKA MIKIKO (JP)
HAGIWARA EMIKO (JP)
FUJII AKIO (JP)
International Classes:
B01J31/24; C07C227/10; C07C227/32; C07F15/00; C07C229/36; (IPC1-7): C07C225/16; B01J31/24; C07C229/22; C07C229/36; C07C229/60; C07C311/16; C07F15/00
Other References:
MOUTOU J. L., ET AL.: "TMSO-TRIFLATE-ASSISTED ADDITION OF ENOLS TO HETEROAROMATIC IMINES OR HYDROXYAMINAL INTERMEDIATES.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 35., no. 37., 1 January 1994 (1994-01-01), GB, pages 6883 - 6886., XP002913851, ISSN: 0040-4039, DOI: 10.1016/0040-4039(94)85031-3
KOBAYASHI S., NAGAYAMA S.: "ALDEHYDES VS ALDIMINES, UNPRECEDENTED REACTIVITY IN THEIR ENOLATE ADDITION REACTIONS.", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62., no. 02., 1 January 1997 (1997-01-01), US, pages 232/233., XP002913852, ISSN: 0022-3263, DOI: 10.1021/jo962010h
PAN Y., MAGUE J. T., FINK M. J.: "SYNTHESIS, STRUCTURE, AND UNUSUAL REACTIVITY OF A D10-D10 PALLADIUM(O) DIMER.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 115., no. 09., 1 January 1993 (1993-01-01), US, pages 3842/3843., XP002913853, ISSN: 0002-7863, DOI: 10.1021/ja00062a087
HAGIWARA E., FUJII A., SODEOKA M.: "ENANTIOSELECTIVE ADDITION OF ENOL SILYL ETHERS TO IMINES CATALYZED BY PALLADIUM COMPLEXES: A NOVEL WAY TO OPTICALLY ACTIVE ACYLALANINEDERIVATIVES.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 120., no. 10., 1 January 1998 (1998-01-01), US, pages 2474/2475., XP002913854, ISSN: 0002-7863, DOI: 10.1021/ja973962n
KOBAYASHI S., NAGAYAMA S.: "ALDEHYDES VS ALDIMINES, UNPRECEDENTED REACTIVITY IN THEIR ENOLATE ADDITION REACTIONS.", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62., no. 02., 1 January 1997 (1997-01-01), US, pages 232/233., XP002913852, ISSN: 0022-3263, DOI: 10.1021/jo962010h
PAN Y., MAGUE J. T., FINK M. J.: "SYNTHESIS, STRUCTURE, AND UNUSUAL REACTIVITY OF A D10-D10 PALLADIUM(O) DIMER.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 115., no. 09., 1 January 1993 (1993-01-01), US, pages 3842/3843., XP002913853, ISSN: 0002-7863, DOI: 10.1021/ja00062a087
HAGIWARA E., FUJII A., SODEOKA M.: "ENANTIOSELECTIVE ADDITION OF ENOL SILYL ETHERS TO IMINES CATALYZED BY PALLADIUM COMPLEXES: A NOVEL WAY TO OPTICALLY ACTIVE ACYLALANINEDERIVATIVES.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 120., no. 10., 1 January 1998 (1998-01-01), US, pages 2474/2475., XP002913854, ISSN: 0002-7863, DOI: 10.1021/ja973962n
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