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Title:
PROCESS FOR THE PRODUCTION OF R(+) alpha -LIPOIC ACID
Document Type and Number:
WIPO Patent Application WO2002030918
Kind Code:
A3
Abstract:
Process for the synthesis of R(+) alpha -lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+) alpha -methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+) alpha -lipoic acid-R(+) alpha -methylbenzylamine; c) purification by re-crystallization of the diastereoisomeric salt of R(+) alpha -lipoic acid-R(+) alpha -methylbenzylamine, in which the re-crystallization solvent consists of a mixture of non-polar/polar solvents; d) separation of the diastereoisomeric salt to obtain R(+) alpha -lipoic acid by reaction of said salt with acids selected from the group consisting of aliphatic hydroxy-carboxylic acids having 3 to 6 carbon atoms and aqueous phosphoric acid.

Inventors:
VILLANI FLAVIO (IT)
NARDI ANTONIO (IT)
SALVI ANNIBALE (IT)
FALABELLA GIOVANNA (IT)
Application Number:
EP0111575W
Publication Date:
August 01, 2002
Filing Date:
October 08, 2001
Export Citation:
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Assignee:
LABORATORIO CHIMICO INTERNAZIONALE S.P.A.
VILLANI, FLAVIO
NARDI, ANTONIO
SALVI, ANNIBALE
FALABELLA, GIOVANNA
International Classes:
C07B57/00; C07C319/06; C07D339/04; C07C323/60; (IPC1-7): C07D339/04; C07D319/06
Foreign References:
US5281722A1994-01-25
EP0702953A21996-03-27
FR4630M
US5621117A1997-04-15
Other References:
TETRAHEDRON: ASYMMETRY, vol. 5, no. 1, 1994, pages 5-8, XP002199866 Great Britan
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