Title:
PYRROLO[2,3-d]PYRIMIDINE COMPOUND OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/022648
Kind Code:
A1
Abstract:
Provided is a novel compound, which selectively and strongly inhibits JAK3, has an excellent effect of inhibiting the proliferation of human peripheral blood monocytes and a high oral absorbability and shows an activity of inhibiting IL-2-induced IFN-γ production in vivo, or a salt thereof and a medicinal composition comprising the same. A compound represented by formula (I) [wherein: X represents -CH=CH-, -NH-, a sulfur atom or an oxygen atom; and n is an integer of 0-2] or a salt thereof.
Inventors:
NAKAMURA MASAYUKI (JP)
YAMANAKA HIROYOSHI (JP)
MITSUYA MORIHIRO (JP)
HARADA TAKAFUMI (JP)
YAMANAKA HIROYOSHI (JP)
MITSUYA MORIHIRO (JP)
HARADA TAKAFUMI (JP)
Application Number:
PCT/JP2016/072258
Publication Date:
February 09, 2017
Filing Date:
July 29, 2016
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D487/04; A61K31/519; A61P19/02; A61P25/00; A61P29/00; A61P37/06
Domestic Patent References:
| WO2013085802A1 | 2013-06-13 | |||
| WO2015054572A1 | 2015-04-16 | |||
| WO2015119126A1 | 2015-08-13 |
Foreign References:
| JP2008528705A | 2008-07-31 | |||
| JP2002518394A | 2002-06-25 |
Other References:
MARK E. FLANAGAN ET AL.: "Discovery of CP- 690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection", J. MED. CHEM., vol. 53, no. 24, 24 November 2010 (2010-11-24), pages 8468 - 8484, XP055222844
See also references of EP 3330271A4
See also references of EP 3330271A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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