Title:
PACKING FOR USE IN SEPARATION
Document Type and Number:
WIPO Patent Application WO/1985/000661
Kind Code:
A1
Abstract:
A packing for use in liquid chromatography for optical resolution of racemic compounds, which comprises a carrier of silica gel having bound thereto a spacer introduced by reacting with a silane treating agent and having chemically bound to the spacer a copper salt of a carboxylic or thiocarboxylic acid selected from among optically active D- or L-2-azetidinecarboxylic acid, proline, hydroxyproline, and allohydroxyproline. Steric bulkiness of the silane treating agent, distance between silica gel and the optically active group, and hydrophobicity are specified to attain an excellent resolving power.
Inventors:
YUKI YOICHI (JP)
ICHIDA AKITO (JP)
ICHIDA AKITO (JP)
Application Number:
PCT/JP1984/000369
Publication Date:
February 14, 1985
Filing Date:
July 20, 1984
Export Citation:
Assignee:
DAICEL CHEM (JP)
International Classes:
B01J20/32; C07B57/00; (IPC1-7): G01N31/08; B01J20/22
Foreign References:
| JPS561350A | 1981-01-09 | |||
| JPS5896062A | 1983-06-07 | |||
| JPS5896062A | 1983-06-07 | |||
| DE3143726A1 | 1983-05-11 | |||
| FR2515645A1 | 1983-05-06 |
Other References:
K. SUGDEN ET AL., J. CHROMATOGR., vol. 192, 1980, pages 228
K. SUGDEN ET AL., J. CHROMATOGR., vol. 192, 1980, pages 228
V. A. DAVANKOV ET AL., CHROMATOGRAPHIA, vol. 13, 1980, pages 677
V. A. DAVANKOV ET AL., CHROMATOGRAPHIA, vol. 13, 1980, pages 677
SHAHAK ET AL., J. AM. CHEM. SOC., vol. 95, 1973, pages 3440
K. SUGDEN ET AL., J. CHROMATOGR., vol. 192, 1980, pages 228
V. A. DAVANKOV ET AL., CHROMATOGRAPHIA, vol. 13, 1980, pages 677
V. A. DAVANKOV ET AL., CHROMATOGRAPHIA, vol. 13, 1980, pages 677
SHAHAK ET AL., J. AM. CHEM. SOC., vol. 95, 1973, pages 3440
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