Title:
PACLITAXEL-LIPID-POLYSACCHARIDE DUAL-TYPE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/242691
Kind Code:
A1
Abstract:
Provided are a paclitaxel-lipid-polysaccharide dual-type conjugate related to general formula I, a preparation method therefor, a use thereof, and a pharmaceutical composition comprising same. The present invention also relates to a series of intermediates used for the preparation of a paclitaxel-lipid-polysaccharide dual-type conjugate, a preparation method therefor, and a use thereof as drug delivery carrier.
Inventors:
CHENG HAIJUN (CN)
HU JINGHUA (US)
LI XIAOHAI (US)
SHI YIKANG (CN)
WANG SI (US)
WANG HUI (CN)
ZHA ANG (CN)
CUI FENGYI (CN)
WANG ANNY (US)
LI DAISY J (US)
ZHANG TAINING (CN)
HU JINGHUA (US)
LI XIAOHAI (US)
SHI YIKANG (CN)
WANG SI (US)
WANG HUI (CN)
ZHA ANG (CN)
CUI FENGYI (CN)
WANG ANNY (US)
LI DAISY J (US)
ZHANG TAINING (CN)
Application Number:
PCT/CN2019/092101
Publication Date:
December 26, 2019
Filing Date:
June 20, 2019
Export Citation:
Assignee:
SANTOLECAN PHARMACEUTICALS LLC (US)
CHENG HAIJUN (CN)
CHENG HAIJUN (CN)
International Classes:
C07D305/14; A61K31/337; A61K31/715; A61K31/728; A61P35/00; C07D405/12; C07D407/06; C07D493/00; C08B37/00; C08B37/08
Foreign References:
| CN103641925A | 2014-03-19 | |||
| CN1705683A | 2005-12-07 | |||
| CN1648132A | 2005-08-03 | |||
| JPH09241293A | 1997-09-16 | |||
| CN201310616253A | 2013-11-27 | |||
| CN201310616253A | 2013-11-27 |
Other References:
IRBY, DANIELLE ET AL.: "Lipid-Drug Conjugate for Enhancing Drug Delivery", MOLECULAR PHARMACEUTICS, vol. 14, 12 January 2017 (2017-01-12), pages 1325 - 1338, XP055582321, DOI: 10.1021/acs.molpharmaceut.6b01027
ANGEW. CHEM., vol. 49, no. 36, 2010, pages 6288 - 308
PRACTICAL DRUGS AND CLINICAL, vol. 19, no. 4, 2016, pages 510 - 517
CANCER RES. TREAT., vol. 43, no. 1, 2011, pages 19 - 23
THER. DELIV., vol. 4, no. 10, 2013, pages 1279 - 1292
J. MED. CHEM., vol. 53, no. 8, 2010, pages 3127 - 3132
EXPERT OPIN. DRUG DELIV., vol. 9, no. 5, 2012, pages 509 - 523
NANOMED NANOBIOTECHNOL, vol. 6, 2014, pages 349 - 368
J. CONTROL RELEASE, vol. 163, no. 3, 2012, pages 322 - 34
MOL. PHARM., vol. 14, no. 5, 2017, pages 1325 - 1338
J. CONTROL RELEASE, vol. 232, 2016, pages 255 - 264
CLIN. CANCER RES., vol. 7, no. 10, 2001, pages 3229 - 3238
ANN. ONCOL., vol. 22, no. 4, 2011, pages 787 - 93
H. C. KOLBM. G. FINNK. B. SHARPLESS: "Click Chemistry: Diverse Chemical Function from a Few Good Reactions", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 40, no. 11, 2001, pages 2004 - 2021, Retrieved from the Internet
SM BERGE ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
STAHLWERMUTH: "Handbook of Pharmaceutical Salts, Properties, Selection, and Use", 2002, WILEY-VCH AND VHCA
See also references of EP 3812376A4
ANGEW. CHEM., vol. 49, no. 36, 2010, pages 6288 - 308
PRACTICAL DRUGS AND CLINICAL, vol. 19, no. 4, 2016, pages 510 - 517
CANCER RES. TREAT., vol. 43, no. 1, 2011, pages 19 - 23
THER. DELIV., vol. 4, no. 10, 2013, pages 1279 - 1292
J. MED. CHEM., vol. 53, no. 8, 2010, pages 3127 - 3132
EXPERT OPIN. DRUG DELIV., vol. 9, no. 5, 2012, pages 509 - 523
NANOMED NANOBIOTECHNOL, vol. 6, 2014, pages 349 - 368
J. CONTROL RELEASE, vol. 163, no. 3, 2012, pages 322 - 34
MOL. PHARM., vol. 14, no. 5, 2017, pages 1325 - 1338
J. CONTROL RELEASE, vol. 232, 2016, pages 255 - 264
CLIN. CANCER RES., vol. 7, no. 10, 2001, pages 3229 - 3238
ANN. ONCOL., vol. 22, no. 4, 2011, pages 787 - 93
H. C. KOLBM. G. FINNK. B. SHARPLESS: "Click Chemistry: Diverse Chemical Function from a Few Good Reactions", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 40, no. 11, 2001, pages 2004 - 2021, Retrieved from the Internet
SM BERGE ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
STAHLWERMUTH: "Handbook of Pharmaceutical Salts, Properties, Selection, and Use", 2002, WILEY-VCH AND VHCA
See also references of EP 3812376A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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