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Title:
PALMITOYL DIPEPTIDE IN WHICH GLYCYLPROLINE OR GLYCYLHYDROXYPROLINE IS BONDED TO PALMITIC ACID, AND A PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2012/128438
Kind Code:
A1
Abstract:
Disclosed are a palmitoyl dipeptide in which glycylproline or glycylhydroxyproline is bonded to palmitic acid, and a production method therefor. The production method for palmitoyl dipeptide of the present invention comprises: a peptide coupling step in which a dipeptide is produced by the peptide coupling of glycine with proline or hydroxyproline; and a palmitoyl reaction step in which a palmitoyl dipeptide is produced by the amide bonding of palmitic acid to the dipeptide. In this way, the prolidase mechanism is activated and hence the production of proline is promoted, and ultimately the recycling of proline is promoted such that it is possible to selectively increase the renewal of collagen in senescent cells within tissue.

Inventors:
LEE, Dong Hee (2 DaeJu Fiore 2 Danji Apt, Gongse-dong Giheung-g, Yongin-si Gyeonggi-do 446-784, 446-784, KR)
이동희 (경기도 용인시 기흥구 공세동 대주피오레2단지아파트 202동 1005호, 446-784 Gyeonggi-do, 446-784, KR)
KIM, Su Hwan (Rm 204, 514-4 Gokbanjeong-dong, Gwonseon-g, Suwon-si Gyeonggi-do 441-400, 441-400, KR)
김수환 (경기도 수원시 권선구 곡반정동 514-4번지 204호, 441-400 Gyeonggi-do, 441-400, KR)
JUNG, Ha Na (Rm 507, 337-75 Woncheon-dong, Yeongtong-g, Suwon-si Gyeonggi-do 443-822, 443-822, KR)
정하나 (경기도 수원시 영통구 원천동 337-75번지 507호, 443-822 Gyeonggi-do, 443-822, KR)
LEE, Da Yea (Rm 316, Kumwoo Hivil 186-25, Heukseok-dong, Dongjak-gu, Seoul 156-861, 156-861, KR)
Application Number:
KR2011/008130
Publication Date:
September 27, 2012
Filing Date:
October 28, 2011
Export Citation:
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Assignee:
CELLINBIO CO., LTD. (1 Digital Empire2, 486 Sin-dong, Yeongtong-g, Suwon-si Gyeonggi-do 443-734, 443-734, KR)
주식회사 셀인바이오 (경기도 수원시 영통구 신동 486 디지털엠파이어2 103동 1207호, 443-734 Gyeonggi-do, 443-734, KR)
LEE, Dong Hee (2 DaeJu Fiore 2 Danji Apt, Gongse-dong Giheung-g, Yongin-si Gyeonggi-do 446-784, 446-784, KR)
이동희 (경기도 용인시 기흥구 공세동 대주피오레2단지아파트 202동 1005호, 446-784 Gyeonggi-do, 446-784, KR)
KIM, Su Hwan (Rm 204, 514-4 Gokbanjeong-dong, Gwonseon-g, Suwon-si Gyeonggi-do 441-400, 441-400, KR)
김수환 (경기도 수원시 권선구 곡반정동 514-4번지 204호, 441-400 Gyeonggi-do, 441-400, KR)
JUNG, Ha Na (Rm 507, 337-75 Woncheon-dong, Yeongtong-g, Suwon-si Gyeonggi-do 443-822, 443-822, KR)
정하나 (경기도 수원시 영통구 원천동 337-75번지 507호, 443-822 Gyeonggi-do, 443-822, KR)
International Classes:
C07K5/06; C07C57/00; C07K1/04; C07K1/06
Domestic Patent References:
WO2010032891A1
Foreign References:
JP2006028058A
JP2005289873A
US7807625B2
US20070048245A1
Attorney, Agent or Firm:
KWON, Young Kyu et al. (#703, Namchang B/D748-16, Yeoksam-dong, Gangnam-gu, Seoul 135-925, 135-925, KR)
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Claims: