Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PAMAM DENDRIMER BASED CEST IMAGING AGENTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/075171
Kind Code:
A3
Abstract:
PAMAM dendrimer based CEST imaging agents, pharmaceutical compositions comprising the same and methods of uses thereof are disclosed.

Inventors:
LESNIAK, Wojciech (10800 Ephraim Dr, Owings Mills, Maryland, 21117, US)
NIMMAGADDA, Sridhar (800 Leadenhall St, Baltimore, Maryland, 21230, US)
OSKOLKOV, Nikita (21 Brookebury Dr Apt 2C, Reisterstown, Maryland, 21136, US)
MCMAHON, Michael (6453 Empty Song Rd, Columbia, Maryland, 21044, US)
SONG, Xiaolei (3900 N. Charles St. Apt. 1206, Baltimore, Maryland, 21218, US)
POMPER, Martin G. (101 Churchwardens Road, Baltimore, Maryland, 21212, US)
Application Number:
US2016/059046
Publication Date:
May 04, 2017
Filing Date:
October 27, 2016
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
THE JOHNS HOPKINS UNIVERSITY (3400 North Charles Street, Baltimore, Maryland, 21218, US)
International Classes:
C08G73/02; A61K49/06; A61K49/12; C08G79/08; C08G83/00
Domestic Patent References:
WO2011053618A22011-05-05
Other References:
WANG, Y. ET AL.: "A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer", CHEMICAL COMMUNICATIONS, vol. 50, no. 85, 2014, pages 12832 - 12835, XP055387145
SHI, X. ET AL.: "Generational, skeletal and substitutional diversities in generation one poly(amidoamine) dendrimers", POLYMER, vol. 46, 2005, pages 3022 - 3034, XP004810421, DOI: doi:10.1016/j.polymer.2005.01.081
YANG, X. ET AL.: "Salicylic acid and analogues as diaCEST MRI contrast agents with highly shifted exchangeable proton frequencies", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 52, 2013, pages 8116 - 8119, XP055386442
YUE, Y. ET AL.: "Synthesis and characterization of G5 PAMAM dendrimer containing daunorubicin for targeting cancer cells", ARCHIVES OF PHARMACAL RESEARCH, vol. 35, no. 2, 2012, pages 343 - 349, XP035021443
LESNIAK, W. G. ET AL.: "Salicylic acid conjugated dendrimers are a tunable, high performance CEST MRI nanoplatform", NANO LETTERS, vol. 16, no. 4, 24 February 2016 (2016-02-24), pages 2248 - 2253, XP055399308
Attorney, Agent or Firm:
CHILDERS, Jeffrey W. (Wade II, Suite 4005430 Wade Park Blvd, Raleigh North Carolina, 27607, US)
Download PDF: