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Title:
PAMAM, SPACER MOLECULE AND CAFESTOL POLYMERS
Document Type and Number:
WIPO Patent Application WO/2014/203229
Kind Code:
A3
Abstract:
The present invention is directed to a polymeric compound with a size in a nanometric scale, useful as a biocompatible carrier for the transport and delivery of active agents into a fish, insect, animal, reptile, bird, human, or plant, wherein said polymeric compound comprises PAMAM (polyamidoamine) dendrimers, a spacer molecule, and cafestol, wherein the polymeric compound of the invention comprises a structure of the kind (cafestol-PAMAM derivative)2-spacer molecule. Use of the compound as a biocompatible carrier for transport and delivery of antithrombotic active agents is disclosed. Procedures for obtaining a polymeric compound comprising the activation of cafestol, activation of polyethylene glycol, and formation of cafestol-PAMAM-PEG-PAMAM-cafestol are also disclosed.

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Inventors:
SILVA SANTOS LEONARDO (CL)
AMALRAJ JOHN (CL)
DURAN LARA ESTEBAN (CL)
NACHTIGALL FABIANE (CL)
Application Number:
PCT/IB2014/063010
Publication Date:
April 09, 2015
Filing Date:
July 10, 2014
Export Citation:
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Assignee:
FUNDACION FRAUNHOFER CHILE RES (CL)
UNIV TALCA (CL)
International Classes:
A61K31/785; A61K47/30; A61K47/48; A61P7/02
Foreign References:
US20120277158A12012-11-01
US20130136697A12013-05-30
US20100028402A12010-02-04
US8313778B22012-11-20
US8252834B22012-08-28
Other References:
LEE, KA ET AL.: "Natural Diterpenes From Coffee, Cafestol and Kahweol Induce Apoptosis Through Regulation of Specificity Protein 1 Expression in Human Malignant Pleural Mesothelioma.", JOURNAL OF BIOMEDICAL SCIENCE ., vol. 19 :60, 2012, pages 1 - 10
Attorney, Agent or Firm:
ALBA PROFESIONALES et al. (Santiago, 86, CL)
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