Title:
PAN-KRAS DEGRADING AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/083256
Kind Code:
A1
Abstract:
Provided in the present invention are a pan-KRAS degrading agent, and a preparation method therefor and the use thereof. Specifically, disclosed in the present invention are a small molecule compound for targeted degradation of the pan-KRAS protein, and a preparation method therefor and the use thereof as a therapeutic agent for preventing and/or treating cancers. The compound of the present invention can effectively degrade and/or inhibit the pan-KRAS protein in cells, and can be used in the preparation of a drug for treating and/or preventing relevant diseases or conditions mediated by pan-KRAS.
Inventors:
YE ZHENGQING (CN)
FENG YAN (CN)
DING CHENLI (CN)
FENG YAN (CN)
DING CHENLI (CN)
Application Number:
PCT/CN2023/125974
Publication Date:
April 25, 2024
Filing Date:
October 23, 2023
Export Citation:
Assignee:
SHANGHAI LEADINGTAC PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D471/04; A61K31/517; A61K31/519; A61P35/00; C07D239/94; C07D239/95; C07D519/00
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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