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Patent Searching and Data


Title:
PARACETAMOL AND DROTAVERINE CONTAINING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2001/007024
Kind Code:
A2
Abstract:
The invention relates to a stable, solid pharmaceutical composition comprising as active ingredients paracetamol and drotaverine hydrochloride in a mixture with one or more organic acid or potassium sorbate as stabilizers, one or more usually used pharmaceutical auxiliary materials and optionally additional active ingredient. As additional active ingredient codein phosphate may be used.

Inventors:
Vitányiné, Morvai Magdolna (Alkotmány u. 31, Budapest, H-1054, HU)
Kovács, Péterné (Görgényi u. 6/B, Budapest, H-1025, HU)
Kálmánné, Máthé Irma (Vasút u. 7/A, Solymár, H-2083, HU)
Jakab, Boglárka (Kmetty u. 14, Budapest, H-1063, HU)
Végeli, Erzsébet (Csuka u. 2, Budapest, H-1131, HU)
Application Number:
PCT/HU2000/000086
Publication Date:
February 01, 2001
Filing Date:
July 28, 2000
Export Citation:
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Assignee:
Chinoin, Gyógyszer És Vegyészeti Termékek Gyára RT. (Tó u. 1-5, Budapest, H-1045, HU)
Vitányiné, Morvai Magdolna (Alkotmány u. 31, Budapest, H-1054, HU)
Kovács, Péterné (Görgényi u. 6/B, Budapest, H-1025, HU)
Kálmánné, Máthé Irma (Vasút u. 7/A, Solymár, H-2083, HU)
Jakab, Boglárka (Kmetty u. 14, Budapest, H-1063, HU)
Végeli, Erzsébet (Csuka u. 2, Budapest, H-1131, HU)
International Classes:
A61K31/47; A61K31/00; A61K31/167; A61K31/485; A61P29/00; A61K31/165; (IPC1-7): A61K31/00
Foreign References:
US5073379A1991-12-17
Other References:
WOJCICKI, JERZY ET AL: "Effect of papaverine and atropine on pharmacokinetics of paracetamol administered orally" POL. J. PHARMACOL. PHARM. (1979), 31(3), 239-43 , XP000974559
See also references of EP 1200088A2
Attorney, Agent or Firm:
Chinoin, Gyógyszer És Vegyészeti Termékek Gyára RT. (Iparjog, Tó u. 1-5, Budapest, H-1045, HU)
Chinoin, Gyógyszer És Vegyészeti Termékek Gyára RT. (Iparjog, Tó u. 1-5, Budapest, H-1045, HU)
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Claims:
Claims
1. A stable, solid pharmaceutical composition comprising as active ingredients paracetamol and drotaverine hydrochloride in a mixture with one or more organic acid or potassium sorbate as stabilizers, one or more usually used pharmaceutical auxiliary materials and optionally additional active ingredient.
2. Composition according to claim 1. containing codein phosphate as additional active ingredient.
3. Composition according to claims 1. and 2. containing as organic acid an organic acid, having a dissociation constant (K) of 10'10'Z.
4. Composition according to claim 3. containing ascorbic acid or citric acid as the organic acid.
5. Composition according to claims 1. and 2. containing as filler and as disintegration facilitating vehicle starch and as glider substances stearic acid, the salts or esters of it or hydrogenated vegetable oils.
6. Composition according to claim 1. containing paracetamol and drotaverine hydrochloride as active ingredients, ascorbic acid, citric acid or potassium sorbate as stabilizer, starch as filler and as disintegration facilitating vehicle, magnesium stearate, stearic acid, hydrogenated vegetable oil or talc as glider, iron (III)oxide or Ariavit Sunset Yellow as colouring vehicle.
7. Compositon according to claims 1. and 2. containing paracetamol, drotaverine hydrochloride and codein phosphate as active ingredients, ascorbic acid, citric acid or potassium sorbate as stabilizer, starch as filler and as disintegration facilitating vehicle, magnesium stearate, stearic acid, hydrogenated vegetable oil or talc as glider, iron (III)oxide or Ariavit Sunset Yellow as colouring vehicle and poly (vinylpyrrolidone).
8. Composition according to claim 1. characterised by that it is in the form of granulates which can be filled into capsules or compressed to tablets.
9. Process for the preparation of a composition according to claim 1. characterised by that wet granulation is used.
10. Process according to claim 9. characterised by that paracetamol, drotaverine hydrochloride, starch, pretreated starch, the stabilizer organic acid and the polyvinylpyrrolidone are mixed in dry form, then the mixture is wetgranulated, dried, assorted, mixed with the glider and the disintegration facilitating substance, and then compressed to tablets.
Description:
INTERNATIONALSEARCHREPORT lnterr ial Application No ... ormaUon on patent family members PCT/HU00/00086 PatentdocumentPublication PatentfamilyPublication citedinsearchreportdatemember(s)date US5073379A17-12-1991DE3830353A15-03-1990 AT102009T15-03-1994 CA1337636A28-11-1995 DE58907077D07-04-1994 EP0358105A14-03-1990 JP2107260A19-04-1990 JP2930607B03-08-1999