Title:
PARALLEL-TYPE MEMBRANE EMULSIFICATION METHOD AND DEVICE FOR PREPARING BIODEGRADABLE POLYMER MICROSPHERES, AND INJECTION FORMULATION PREPARATION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/027401
Kind Code:
A1
Abstract:
The present invention relates to a method and device for preparing biodegradable polymer microspheres, and an injection formulation preparation method using same and, more specifically, to a parallel-type continuous reaction membrane emulsification method and device which can not only adjust the size but also mass produce biodegradable polymer microspheres maintaining a uniform size while maintaining the spherical shape, and a method for preparing a microsphere injection formulation composition comprising same. According to the parallel-type continuous reaction membrane emulsification method and device for preparing biodegradable polymer microspheres according to one embodiment of the present invention, since the particle size of the biodegradable polymer microspheres can easily be adjusted, and also spherical particles of a uniform size can easily be prepared, the method and device are suitable for mass production. According to the injection formulation preparation method according to one embodiment of the present invention, the biodegradable polymer microspheres, which have a low injection pressure due to uniform particle size distribution and are optimized for drug encapsulation due to enhanced mechanical strength, may be utilized for an injection formulation for drugs or medical devices.
Inventors:
JEONG MINWOOK (KR)
Application Number:
PCT/KR2022/012123
Publication Date:
March 02, 2023
Filing Date:
August 12, 2022
Export Citation:
Assignee:
JEONG MINWOOK (KR)
International Classes:
A61K9/16; A61J3/00; A61J3/02; A61K9/00; B01J2/06; B01J19/18
Foreign References:
| KR102051044B1 | 2019-12-02 | |||
| KR20190085500A | 2019-07-18 | |||
| KR20140135337A | 2014-11-26 | |||
| KR20190062709A | 2019-06-07 | |||
| KR20200009689A | 2020-01-30 | |||
| KR102377283B1 | 2022-03-22 | |||
| KR101105292B1 | 2012-01-17 | |||
| KR100566573B1 | 2006-03-31 | |||
| KR102089560B1 | 2020-03-17 | |||
| KR102101969B1 | 2020-04-22 |
Other References:
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LANGER, R.: "New methods of drug delivery", SCIENCE, vol. 249, 1990, pages 1527 - 1533, XP000169082, DOI: 10.1126/science.2218494
LANGER, R., CHEM. ENG. COMMUN., vol. 6, 1980, pages 1 - 48
LANGER, R. S.PEPPAS, N. A., BIOMATERIALS, vol. 2, 1981, pages 201 - 214
HELLER, J., CRC CRIT. REV. THER. DRUG CATTRIER SYST., vol. 1, no. 1, 1984, pages 39 - 90
HOLLAND, S.J.TIGHE, B. J.GOULD, P. L., J. CONTROLLED RELEASE, 1986, pages 155 - 180
CROTTS, G.PARK, T.G., J. CONTROL. RELEASE, vol. 44, 1997, pages 123 - 134
LEONARD, N.B.MICHAEL, L. H.LEE, M.M., J. PHARM. SCI., vol. 84, pages 707 - 712
Attorney, Agent or Firm:
HYUNMOON PATENT (KR)
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