Title:
PARP7 ENZYME INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/156708
Kind Code:
A1
Abstract:
Provided are a PARP7 enzyme inhibitor, a composition containing the inhibitor and the use thereof, synthetic methods for the preparation of PARP7 enzyme inhibitor and useful intermediates thereof.
Inventors:
LI HAIJUN (CN)
CHEN MINGMING (CN)
KANG DI (CN)
LI QINGLONG (CN)
ZHANG LEI (CN)
YAN MAN (CN)
LONG WEI (CN)
WANG YANPING (CN)
ZHANG HAO (CN)
MA CUNBO (CN)
LI AMIN (CN)
CHEN MINGMING (CN)
KANG DI (CN)
LI QINGLONG (CN)
ZHANG LEI (CN)
YAN MAN (CN)
LONG WEI (CN)
WANG YANPING (CN)
ZHANG HAO (CN)
MA CUNBO (CN)
LI AMIN (CN)
Application Number:
PCT/CN2022/072728
Publication Date:
July 28, 2022
Filing Date:
January 19, 2022
Export Citation:
Assignee:
JACOBIO PHARMACEUTICALS CO LTD (CN)
International Classes:
C07D403/12; A61K31/496; A61P35/00; C07D401/12; C07D401/14; C07D405/14; C07D413/14; C07D417/12; C07D417/14
Domestic Patent References:
| WO2021087018A1 | 2021-05-06 | |||
| WO2019212937A1 | 2019-11-07 | |||
| WO2020223229A1 | 2020-11-05 | |||
| WO2001087870A1 | 2001-11-22 | |||
| WO1987004928A1 | 1987-08-27 | |||
| WO2016192657A1 | 2016-12-08 | |||
| WO2017079641A1 | 2017-05-11 | |||
| WO2008013838A2 | 2008-01-31 | |||
| WO2019055966A2 | 2019-03-21 |
Foreign References:
| CN103833756A | 2014-06-04 | |||
| CN107793362A | 2018-03-13 |
Other References:
DATABASE REGISTRY 20 April 2016 (2016-04-20), ANONYMOUS : "Pyrimidine, 5-cyclopropyl-2-(1-piperazinyl)- (CA INDEX NAME) ", XP055933729, retrieved from STN Database accession no. 1894032-21-3 (+ 1895860-02-2， 2446939-41-7， 734526-25-1， 1519948-60-7， 1894543-01-1， 2436650-59-6， 1418212-97-1， 1893543-89-9， 1368790-87-7， 2055228-77-6， 1893543-74-2， 1890456-33-3， 2114725-65-2， 745066-18-6， 1701516-25-7， 88268-08-0， 1823912-09-9， 2097465-78-4， 1339718-54-5 )
LONG MADELINE F.; ENGERS JULIE L.; CHANG SICHEN; ZHAN XIAOYAN; WEINER REBECCA L.; LUSCOMBE VINCENT B.; RODRIGUEZ ALICE L.; CHO HYE: "Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4positive allosteric modulator (PAM) chemotype via scaffold hopping", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 22, 1 January 1900 (1900-01-01), Amsterdam NL , pages 4999 - 5001, XP085247433, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.10.016
TSUNO N. ET AL.: "Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 20, 7 September 2016 (2016-09-07), pages 4930 - 4935, XP002796679
LONG MADELINE F.; ENGERS JULIE L.; CHANG SICHEN; ZHAN XIAOYAN; WEINER REBECCA L.; LUSCOMBE VINCENT B.; RODRIGUEZ ALICE L.; CHO HYE: "Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4positive allosteric modulator (PAM) chemotype via scaffold hopping", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 22, 1 January 1900 (1900-01-01), Amsterdam NL , pages 4999 - 5001, XP085247433, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.10.016
TSUNO N. ET AL.: "Discovery of novel 2',4'-dimethyl-[4,5'-bithiazol]-2-yl amino derivatives as orally bioavailable TRPV4 antagonists for the treatment of pain: Part 1.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 26, no. 20, 7 September 2016 (2016-09-07), pages 4930 - 4935, XP002796679
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