Title:
PARTICLE-BASED LIGAND ASSAY WITH EXTENDED DYNAMIC RANGE
Document Type and Number:
WIPO Patent Application WO2003046514
Kind Code:
A3
Abstract:
This invention relates to methods of assaying one or more analytes simultaneously. The assay of this invention are capable of providing wide dynamic range and rapid processing times. A wide dynamic working range is achieved by simultaneously incubating a sample which may contain the analyte(s) of interest with two or more independently determinable classes of particles coated with an analyte-specific binding partner. The two or more particle classes differ from each other at least in size. The analyte concentration is obtained from readings derived from these two classes by means of a combined standard curve.
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Inventors:
BELL MICHAEL L
Application Number:
PCT/US2002/038257
Publication Date:
July 31, 2003
Filing Date:
November 27, 2002
Export Citation:
Assignee:
BECKMAN COULTER INC (US)
International Classes:
G01N15/14; G01N21/78; G01N33/543; G01N33/566; (IPC1-7): G01N33/53; G01N33/543; G01N33/551
Domestic Patent References:
| WO1989011101A1 | 1989-11-16 |
Foreign References:
| US5585241A | 1996-12-17 | |||
| US5981180A | 1999-11-09 | |||
| US5851777A | 1998-12-22 | |||
| US6248597B1 | 2001-06-19 |
Other References:
See also references of EP 1448990A4
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