Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PARTICLES COMPRISING BILIRUBIN DERIVATIVE AND METAL
Document Type and Number:
WIPO Patent Application WO/2018/208137
Kind Code:
A2
Abstract:
The present invention relates to bilirubin derivative particles comprising a bilirubin derivative and a metal, a use thereof, and a manufacturing method therefor. Since the bilirubin derivative particles of the present invention form coordinate bonds with various metals, the particles can be used in MR diagnosis, CT diagnosis, photo-acoustic diagnosis, PET diagnosis, or optical diagnosis. Since the bilirubin derivative particles of the present invention bind to a platinum-based anticancer drug and are decomposed by light/active oxygen stimulation, the particles can release the anticancer drug encapsulated therein to the outside, and since the particles exhibit anti-inflammatory and anticancer activity, the particles are materials in the concept of theranostics that can be used for diagnosis as well as treatment. In addition, since the bilirubin derivative particles of the present invention are reactive to active oxygen species, the particles can be also useful as a composition, a sensor, a kit, a contrast agent, or an apparatus for detecting the type and concentration of active oxygen species.

Inventors:
JON SANG YONG (KR)
LEE DONG YUN (KR)
LEE YONG HYUN (KR)
YOO DO HYUN (KR)
JUNG WON SIK (KR)
Application Number:
PCT/KR2018/005515
Publication Date:
November 15, 2018
Filing Date:
May 14, 2018
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K51/04; A61K31/409; A61K49/18; A61K51/12
Foreign References:
KR20170059597A2017-05-31
KR101681299B12016-12-05
Other References:
LEE ET AL., J. MED. CHEM., vol. 51, no. 20, 2008, pages 6442 - 6449
JORLEMON ET AL., CHEM. COMMUN., vol. 46, 2010, pages 1377 - 1393
See also references of EP 3622969A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
Download PDF: