Title:
PARTICLES OF SPHERICALLY AGGLOMERATED LACTOSE FOR DIRECT COMPRESSION AND METHOD OF PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/039698
Kind Code:
A8
Abstract:
Many active pharmaceutical ingredients are not directly compressible, therefore addition of pharmaceutical excipients is necessary. Fillers are essential pharmaceutical excipients, among which sugars are commonly employed, especially lactose. It is required that such substances have good flowability and compressibility. The present invention enables a simple and industry applicable production of particles of spherically agglomerated lactose that have suitable flow properties, excellent compression characteristics and reduce or prevent occurrence of segregation in mixture for production of solid dosage forms. They are porous spherical agglomerates. Particles of spherically agglomerated lactose comprise prism-like primary particles that are radially arranged and form a bigger agglomerate structure. Particles of spherically agglomerated lactose have suitable size, are highly breakable, have relatively high specific surface area and enable production of tablets with high tensile strength.
Inventors:
LAMEŠIĆ DEJAN (SI)
LAVRIČ ZORAN (SI)
ILIĆ ILIJA (SI)
PLANINŠEK ODON (SI)
LAVRIČ ZORAN (SI)
ILIĆ ILIJA (SI)
PLANINŠEK ODON (SI)
Application Number:
PCT/SI2015/000029
Publication Date:
May 06, 2016
Filing Date:
September 10, 2015
Export Citation:
Assignee:
LAMEŠIĆ DEJAN (SI)
LAVRIČ ZORAN (SI)
ILIĆ ILIJA (SI)
LAVRIČ ZORAN (SI)
ILIĆ ILIJA (SI)
International Classes:
A61K47/26; A61K9/14; A61K9/20; A61K31/00
Attorney, Agent or Firm:
ITEM D.O.O. (1000 Ljubljana, SI)
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