Title:
PATHOGENIC AND COMMENSAL VACCINE ANTIGENS
Document Type and Number:
WIPO Patent Application WO2002077648
Kind Code:
A3
Abstract:
The invention provides methods of screening commensal and pathogenic bacteria for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.
Inventors:
ROBINSON ANDREW (GB)
GORRINGE ANDREW RICHARD (GB)
HUDSON MICHAEL JOHN (GB)
BRACEGIRDLE PHILIPPA (GB)
WEST DAVID MCKAY (GB)
OLIVER KERRY JANE (GB)
KROLL JOHN SIMON (GB)
LANGFORD PAUL RICHARD (GB)
GORRINGE ANDREW RICHARD (GB)
HUDSON MICHAEL JOHN (GB)
BRACEGIRDLE PHILIPPA (GB)
WEST DAVID MCKAY (GB)
OLIVER KERRY JANE (GB)
KROLL JOHN SIMON (GB)
LANGFORD PAUL RICHARD (GB)
Application Number:
PCT/GB2002/001399
Publication Date:
December 31, 2003
Filing Date:
March 22, 2002
Export Citation:
Assignee:
HEALTH PROT AGENCY (GB)
IMP COLLEGE INNOVATIONS LTD (GB)
ROBINSON ANDREW (GB)
GORRINGE ANDREW RICHARD (GB)
HUDSON MICHAEL JOHN (GB)
BRACEGIRDLE PHILIPPA (GB)
WEST DAVID MCKAY (GB)
OLIVER KERRY JANE (GB)
KROLL JOHN SIMON (GB)
LANGFORD PAUL RICHARD (GB)
IMP COLLEGE INNOVATIONS LTD (GB)
ROBINSON ANDREW (GB)
GORRINGE ANDREW RICHARD (GB)
HUDSON MICHAEL JOHN (GB)
BRACEGIRDLE PHILIPPA (GB)
WEST DAVID MCKAY (GB)
OLIVER KERRY JANE (GB)
KROLL JOHN SIMON (GB)
LANGFORD PAUL RICHARD (GB)
International Classes:
G01N27/62; A61K39/095; A61K39/395; A61P31/04; C07K14/22; C07K16/12; C12N15/09; G01N27/64; G01N33/53; G01N33/569; (IPC1-7): C07K14/22; A61K39/095; G01N33/569
Domestic Patent References:
| WO2000050074A2 | 2000-08-31 | |||
| WO2000022430A2 | 2000-04-20 | |||
| WO1999007741A1 | 1999-02-18 | |||
| WO1999009176A1 | 1999-02-25 | |||
| WO2000066791A1 | 2000-11-09 |
Other References:
TRONCOSO G ET AL: "ANTIGENIC CROSS-REACTIVITY BETWEEN OUTER MEMBRANE PROTEINS OF NEISSERIA MENINGITIDIS AND COMMENSAL NEISSERIA SPECIES", FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, ELSEVIER SCIENCE B.V., AMSTERDAM, NL, vol. 27, no. 2, February 2000 (2000-02-01), pages 103 - 109, XP000946807, ISSN: 0928-8244
DATABASE SWALL [online] 1 October 2000 (2000-10-01), XP002237229, retrieved from EBI Database accession no. Q9JWY0
DATABASE SWALL [online] 1 October 2000 (2000-10-01), XP002237229, retrieved from EBI Database accession no. Q9JWY0
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