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Patent Searching and Data


Title:
PATTERN RECOGNITION RECEPTOR AGONIST PRODRUGS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/140001
Kind Code:
A1
Abstract:
Provided herein are a selective pattern recognition receptor (PRR) agonist and a method of selectively activating a PRR. The selective PRR agonist includes a nucleic acid agonist and a macromolecule conjugated to the nucleic acid agonist. The method includes administering the selective PRR agonist to a subject, and cleaving at least a portion of the macromolecule conjugated to the nucleic acid agonist, the cleaving of at least a portion of the macromolecule permitting the agonist to bind a PRR.

Inventors:
WILSON JOHN T (US)
Application Number:
PCT/US2019/012929
Publication Date:
July 18, 2019
Filing Date:
January 09, 2019
Export Citation:
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Assignee:
UNIV VANDERBILT (US)
International Classes:
A61K39/00; A61K39/39
Foreign References:
US20140287023A12014-09-25
Other References:
MISHRA ET AL.: "PEGylation in anti-cancer therapy: An overview", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 11, no. 3, 14 September 2015 (2015-09-14), pages 337 - 348, XP055444010, doi:10.1016/j.ajps.2015.08.011
HEIDEL ET AL.: "Cyclodextrin-Containing Polymers: Versatile Platforms of Drug Delivery Materials", JOURNAL OF DRUG DELIVERY, vol. 2012, 2012, pages 1 - 17, XP055625653
Attorney, Agent or Firm:
RITCHIE, Sean P. et al. (US)
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