Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PD-1 ANTIBODIES
Document Type and Number:
WIPO Patent Application WO/2018/068336
Kind Code:
A1
Abstract:
The present invention provides antibodies that bind human programmed cell death 1 (PD-1), and may be useful for treating cancer alone and in combination with chemotherapy and other cancer therapeutics.

Inventors:
TSUN ANDY (CN)
CHEN CHENG (CN)
LIU XIAOLIN (CN)
YU MICHEAL (CN)
Application Number:
PCT/CN2016/102238
Publication Date:
April 19, 2018
Filing Date:
October 15, 2016
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
INNOVENT BIOLOGICS SUZHOU CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00
Domestic Patent References:
WO2013181452A12013-12-05
WO2013079174A12013-06-06
WO2013173223A12013-11-21
WO2012177624A22012-12-27
WO2008156712A12008-12-24
Other References:
WANG ET AL., CANCER IMMUNOL RES, vol. 2, no. 9, 2014, pages 846
HAMID ET AL., N ENGL J MED, vol. 369, 2013, pages 2
C. WANG ET AL.: "In Vitro Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and In Vivo Toxicology in Non-Human Primates", CANCER IMMUNOLOGY RESEARCH, vol. 2, no. 9, 28 May 2014 (2014-05-28), pages 846 - 856, XP055563054, DOI: 10.1158/2326-6066.CIR-14-0040
JAMES LARKIN ET AL.: "Combined Nivolumab and Ipilimumab or Monotherapt in Untreated Melanoma", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 373, no. 1, July 2015 (2015-07-01), pages 23 - 34
LEILA KHOJA ET AL.: "Pembrolizumab", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 348, 18 December 2015 (2015-12-18), pages 124, XP055316831, DOI: 10.1186/s40425-015-0078-9
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTES OF HEALTH, BETHESDA
CHOTHIA ET AL.: "Canonical structures for the hypervariable regions of immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 196, 1987, pages 901 - 917, XP024010426, DOI: 10.1016/0022-2836(87)90412-8
AL-LAZIKANI ET AL.: "Standard conformations for the canonical structures of immunoglobulins", JOURNAL OF MOLECULAR BIOLOGY, vol. 273, 1997, pages 927 - 948, XP004461383, DOI: 10.1006/jmbi.1997.1354
NORTH ET AL.: "A New Clustering of Antibody CDR Loop Conformations", JOURNAL OF MOLECULAR BIOLOGY, vol. 406, 2011, pages 228 - 256, XP028129711, DOI: 10.1016/j.jmb.2010.10.030
DEUTSCHER, METHODS IN ENZYMOLOGY, vol. 182, 1990, pages 83 - 89
SCOPES: "Protein Purification: Principles and Practice", 1994, SPRINGER
A. GENNARO ET AL.: "Remington: The Science and Practice of Pharmacy", 1995, MACK PUBLISHING
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2012, COLD SPRING HARBOR LABORATORY PRESS
ESTEP, P. ET AL.: "High throughput solution-based measurement of antibody-antigen affinity and epitope binning", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
See also references of EP 3383915A4
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
Download PDF: