Title:
PD-1 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF, AND MEDICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/085847
Kind Code:
A1
Abstract:
The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and a medical application thereof, and further provides a chimeric antibody comprising a complementarity-determining region (CDR) of the antibody, a humanized antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and a purpose of the antibody in preparing medicine for treating diseases or symptoms.
Inventors:
YUAN JIJUN (CN)
QU XIANGDONG (CN)
LIN JUFANG (CN)
YE XIN (CN)
CAO GUOQING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
ZHANG LEI (CN)
YANG LI (CN)
QU XIANGDONG (CN)
LIN JUFANG (CN)
YE XIN (CN)
CAO GUOQING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
ZHANG LEI (CN)
YANG LI (CN)
Application Number:
PCT/CN2014/091090
Publication Date:
June 18, 2015
Filing Date:
November 14, 2014
Export Citation:
Assignee:
SHANGHAI HENGRUI PHARM CO LTD (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N1/19; C12N1/21; C12N15/13; C12N15/70; C12N15/81
Domestic Patent References:
| WO2009114335A2 | 2009-09-17 |
Foreign References:
| CN102892785A | 2013-01-23 | |||
| CN1259961A | 2000-07-12 | |||
| US4683195A | 1987-07-28 |
Other References:
J. BIOL. CHEM, vol. 243, 1968, pages 3558
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest", 1991
"The Immunoglobulin FactsBook", 2001
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
See also references of EP 3081576A4
KABAT, EA ET AL.: "Sequences of Proteins of Immunological Interest", 1991
"The Immunoglobulin FactsBook", 2001
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
MULLIS ET AL., COLD SPRING HARBOR SYMP. OUANT. BIOL., vol. 51, 1987, pages 263
"PCR TECHNOLOGY", 1989, STOCKTON PRESS
See also references of EP 3081576A4
Attorney, Agent or Firm:
GE CHENG & CO. LTD (CN)
北京戈程知识产权代理有限公司 (CN)
北京戈程知识产权代理有限公司 (CN)
Download PDF: