Title:
PD-1-BINDING MOLECULES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/019846
Kind Code:
A8
Abstract:
The present invention is directed to selected anti-PD-1 antibodies capable of binding to both cynomolgus monkey PD-1 and to human PD-1 : PD-1 mAb 1, PD-1 mAb 2, PD-1 mAb 3, PD-1 mAb 4, PD-1 mAb 5, PD-1 mAb 6, PD-1 mAb 7, PD-1 mAb 8, PD-1 mAb 9, PD-1 mAb 10, PD-1 mAb 11, PD-1 mAb 12, PD-1 mAb 13, PD-1 mAb 14, or PD-1 mAb 15, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to PD-1 -binding molecules that comprise PD-1 binding fragments of such anti-PD-1 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such PD-1 -binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of using molecules that bind PD-1 for stimulating immune responses, as well as methods of detecting PD-1.
Inventors:
SHAH KALPANA (US)
SMITH DOUGLAS H (US)
LA MOTTE-MOHS ROSS (US)
JOHNSON LESLIE S (US)
MOORE PAUL A (US)
BONVINI EZIO (US)
KOENIG SCOTT (US)
SMITH DOUGLAS H (US)
LA MOTTE-MOHS ROSS (US)
JOHNSON LESLIE S (US)
MOORE PAUL A (US)
BONVINI EZIO (US)
KOENIG SCOTT (US)
Application Number:
PCT/US2016/044430
Publication Date:
January 25, 2018
Filing Date:
July 28, 2016
Export Citation:
Assignee:
MACROGENICS INC (US)
International Classes:
A61K39/00; A61K39/395; C07K16/00
Attorney, Agent or Firm:
AUERBACH, Jeffrey, I. et al. (US)
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