Title:
PD-1 CAR-T CELL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/177575
Kind Code:
A1
Abstract:
Provided are a PD-1 CAR-T cell, a preparation method therefor, and an application thereof. By means of chimeric antigen receptor-modified T cell transformation, PD-1-CD8TM-4-1BB-CD3ζ molecules are expressed in a T cell. The CAR T cell prepared by the method can specifically recognize and bind with tumor cells with high PDL-1 protein expression, and is applicable to preparation of a drug for preventing and treating tumor diseases.
Inventors:
LI HUASHUN (CN)
Application Number:
PCT/CN2016/092578
Publication Date:
October 19, 2017
Filing Date:
September 19, 2016
Export Citation:
Assignee:
LI HUASHUN (CN)
International Classes:
C12N5/10; A61K35/17; A61P35/00; C12N15/62; C12N15/867
Domestic Patent References:
| WO2015095895A1 | 2015-06-25 |
Foreign References:
| CN106163547A | 2016-11-23 | |||
| CN106062185A | 2016-10-26 |
Other References:
JI, GUANGHUI: "Advances in Adoptive Cellular Immunotherapy for Cancer", TRANSLATIONAL MEDICINE JOURNAL, vol. 4, no. 4, 31 August 2015 (2015-08-31)
Attorney, Agent or Firm:
SUZHOU GROUNZE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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