Title:
PD-L1/LAG-3 BISPECIFIC ANTIBODY PREPARATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/017468
Kind Code:
A1
Abstract:
Provided are a pharmaceutical preparation containing a PD-L1/LAG-3 double antibody, a buffer, a stabilizer, a surfactant and a chelating agent, and the corresponding therapeutic or preventive use thereof.
Inventors:
YAO TIANYI (CN)
MA YIDONG (CN)
WANG YINJUE (CN)
MA YIDONG (CN)
WANG YINJUE (CN)
Application Number:
PCT/CN2021/107878
Publication Date:
January 27, 2022
Filing Date:
July 22, 2021
Export Citation:
Assignee:
INNOVENT BIOLOGICS SUZHOU CO LTD (CN)
International Classes:
A61K39/395; A61K9/08; A61K9/19; A61P35/00; A61P37/02; C07K16/28
Domestic Patent References:
| WO2019129137A1 | 2019-07-04 |
Foreign References:
| CN109970860A | 2019-07-05 | |||
| CN105435222A | 2016-03-30 | |||
| CN106620691A | 2017-05-10 | |||
| CN104940926A | 2015-09-30 | |||
| CN106913869A | 2017-07-04 | |||
| CN109970856A | 2019-07-05 | |||
| CN110305210A | 2019-10-08 | |||
| CN107686520A | 2018-02-13 | |||
| CN109970857A | 2019-07-05 | |||
| CN110678484A | 2020-01-10 | |||
| CN202010720248A | 2020-07-23 | |||
| CN2020073964W | 2020-01-23 |
Other References:
"Peptide and Protein Drug Delivery", 1991, MARCEL DEKKER, INC, pages: 247 - 301
JONES, A., ADV. DRUG DELIVERY REV., vol. 10, 1993, pages 29 - 90
ROWE ET AL.: "The Handbook of Pharmaceutical Excipients", 2003, AMERICAN PHARMACEUTICALS ASSOCIATION
GENNARO: "Remington: the Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
TUGCU: "Maximizing productivity of chromatography steps for purification of monoclonal antibodies", BIOTECHNOLOGY AND BIOENGINEERING, vol. 99, 2008, pages 599 - 613, XP002556043, DOI: 10.1002/bit.21604
KELLEY ET AL.: "Weak partitioning chromatography for anion exchange purification of monoclonal antibodies", BIOTECHNOLOGY AND BIOENGINEERING, vol. 101, 2008, pages 553 - 566
B. MINOWP. ROGGEK. THOMPSON, BIOPROCESS INTERNATIONAL, vol. 10, no. 6, 2012, pages 48 - 57
NATIONAL PHARMACOPOEIA COMMITTEE: "Pharmacopoeia of the People 's Republic of China", 2015, article "Test for Visible Particles"
JONES, A., ADV. DRUG DELIVERY REV., vol. 10, 1993, pages 29 - 90
ROWE ET AL.: "The Handbook of Pharmaceutical Excipients", 2003, AMERICAN PHARMACEUTICALS ASSOCIATION
GENNARO: "Remington: the Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
TUGCU: "Maximizing productivity of chromatography steps for purification of monoclonal antibodies", BIOTECHNOLOGY AND BIOENGINEERING, vol. 99, 2008, pages 599 - 613, XP002556043, DOI: 10.1002/bit.21604
KELLEY ET AL.: "Weak partitioning chromatography for anion exchange purification of monoclonal antibodies", BIOTECHNOLOGY AND BIOENGINEERING, vol. 101, 2008, pages 553 - 566
B. MINOWP. ROGGEK. THOMPSON, BIOPROCESS INTERNATIONAL, vol. 10, no. 6, 2012, pages 48 - 57
NATIONAL PHARMACOPOEIA COMMITTEE: "Pharmacopoeia of the People 's Republic of China", 2015, article "Test for Visible Particles"
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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