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Title:
PD-1/PD-L1 SMALL-MOLECULE INHIBITOR AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/076343
Kind Code:
A1
Abstract:
Disclosed are a PD-1/PD-L1 small-molecule inhibitor and a preparation method therefor and use thereof. In particular, disclosed are a compound which has a structure as shown in formula L, a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt, hydrate or solvate thereof, the specific definitions of which are detailed in the description. Also disclosed are an excellent effect of such a compound on the inhibition PD-1/PD-L1.

Inventors:
WANG, Zhe (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
FAN, Guoqin (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
ZENG, Zhihong (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
WANG, Xiaoguang (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
JIANG, Rongzhen (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
Application Number:
CN2018/110869
Publication Date:
April 25, 2019
Filing Date:
October 18, 2018
Export Citation:
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Assignee:
SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD. (Rm 7401-7402, 3F & 4F. Building 7, 4289 Jindu Road, Minhang District, Shanghai 8, 201108, CN)
International Classes:
C07D215/12; A61P35/00; C07D239/74; C07D307/79; C07D311/04; C07D311/76; C07D319/20; C07D333/54; C07D405/04; C07D491/048; C07D513/04
Domestic Patent References:
WO2017066227A12017-04-20
WO2017106634A12017-06-22
WO2015160641A22015-10-22
Foreign References:
CN104159911A2014-11-19
CN105849092A2016-08-10
Attorney, Agent or Firm:
XU AND PARTNERS, LLC. (Room 106, Building No. 1 Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District, Shanghai 3, 200333, CN)
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