Title:
PENICILONES DERIVATIVE AND APPLICATION THEREOF AS ANTI-RESISTANT BACTERIA DRUG
Document Type and Number:
WIPO Patent Application WO/2018/141263
Kind Code:
A1
Abstract:
A penicilones derivative and an application thereof as an anti-resistant bacteria drug, in particular relating to a compound of formula I, stereoisomers thereof, tautomers thereof, solvates thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof or solvates of the salts thereof, characterized in that the compound of formula I has the following structure: formula I. The compound shows strong antibacterial activity against methicillin-resistant Staphylococcus aureus, and the antibacterial activity thereof is superior to that of oxacillin sodium and comparable to that of vancomycin hydrochloride.
Inventors:
CHEN MIN (CN)
Application Number:
PCT/CN2018/075069
Publication Date:
August 09, 2018
Filing Date:
February 02, 2018
Export Citation:
Assignee:
YANGZHOU BLUE BIOMEDICAL TECH COMPANY LIMITED (CN)
International Classes:
C07D311/76; A61K31/352; A61P31/04
Domestic Patent References:
| WO1998037890A1 | 1998-09-03 |
Foreign References:
| JP2005220040A | 2005-08-18 | |||
| CN104311525A | 2015-01-28 | |||
| CN103910708A | 2014-07-09 |
Other References:
CHEN, MIN ET AL.: "Penicilones A-D, Anti-MRSA Azaphilones from the Marine-Derived Fungus Penicillium Janthinellum HK 1-6", JOURNAL OF NATURAL PRODUCTS, vol. 80, no. 4, 1 March 2017 (2017-03-01), pages 1081 - 1086, XP055532569
DANG, N. Q. ET AL.: "Cohaerins C-F, Four Azaphilones from the Xylariaceous Fungus Annulohypoxylon Cohaerens", TETRAHEDRON, vol. 62, no. 26, October 2006 (2006-10-01), pages 6349 - 6354, XP025002152
LIN, LONG ET AL.: "Synthesis and Antifungal Activity of Novel Sclerotiorin Analogues", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 60, no. 18, 9 May 2012 (2012-05-09), pages 4480 - 4491, XP055532590
LIN, LONG ET AL.: "Design, Synthesis and Fungicidal Activity of Novel Sclerotiorin Derivatives", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 80, no. 5, November 2012 (2012-11-01), pages 682 - 692, XP055169975
DANG, N. Q. ET AL.: "Cohaerins C-F, Four Azaphilones from the Xylariaceous Fungus Annulohypoxylon Cohaerens", TETRAHEDRON, vol. 62, no. 26, October 2006 (2006-10-01), pages 6349 - 6354, XP025002152
LIN, LONG ET AL.: "Synthesis and Antifungal Activity of Novel Sclerotiorin Analogues", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 60, no. 18, 9 May 2012 (2012-05-09), pages 4480 - 4491, XP055532590
LIN, LONG ET AL.: "Design, Synthesis and Fungicidal Activity of Novel Sclerotiorin Derivatives", CHEMICAL BIOLOGY & DRUG DESIGN, vol. 80, no. 5, November 2012 (2012-11-01), pages 682 - 692, XP055169975
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