Title:
PENTACYCLIC TRITERPENE-PEPTIDE CONJUGATE, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/095830
Kind Code:
A1
Abstract:
Provided is a pentacyclic triterpene-peptide conjugate, and a preparation method, a pharmaceutical composition and a use thereof. The pentacyclic triterpene-peptide conjugate has an antibacterial effect, and in particular has a significant antibacterial effect on gram-positive bacteria.
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Inventors:
LIU KELIANG (CN)
NA HEYA (CN)
LI XIANGPENG (CN)
WANG CHENHONG (CN)
NA HEYA (CN)
LI XIANGPENG (CN)
WANG CHENHONG (CN)
Application Number:
PCT/CN2015/097685
Publication Date:
June 23, 2016
Filing Date:
December 17, 2015
Export Citation:
Assignee:
INST PHARM & TOXICOLOGY AMMS (CN)
International Classes:
C07K5/068; A61K31/56; A61K38/05; A61K38/06; A61K38/07; A61K38/08; A61P31/04; C07J61/00; C07K5/09; C07K5/11; C07K7/06
Foreign References:
| US20060166867A1 | 2006-07-27 |
Other References:
WANG, CHAO ET AL.: "Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor: A Promising Strategy for Discovering New Antiviral Therapeutics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 17, 26 August 2014 (2014-08-26)
HORIUCHI, KUMIKO ET AL.: "Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE", BIOL. PHARM. BULL., vol. 30, no. 6, 16 March 2007 (2007-03-16)
HORIUCHI, KUMIKO ET AL.: "Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE", BIOL. PHARM. BULL., vol. 30, no. 6, 16 March 2007 (2007-03-16)
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
中国国际贸易促进委员会专利商标事务所 (CN)
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