Title:
PENTOSAN POLYSULFATE AND MEDICINE CONTAINING PENTOSAN POLYSULFATE
Document Type and Number:
WIPO Patent Application WO/2019/124363
Kind Code:
A1
Abstract:
The present invention provides a pentosan polysulfate having an uronic acid content of 7.0-15.0 mass% and an acetyl group content of 0-2.0 mass% or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof. The pentosan polysulfate or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, is useful as a pH buffering agent and as an active ingredient of a medicine for the prevention and/or treatment of diseases caused by the abnormal elevation of the function of FGF-2.
Inventors:
ISHIKAWA SUGURU (JP)
Application Number:
PCT/JP2018/046537
Publication Date:
June 27, 2019
Filing Date:
December 18, 2018
Export Citation:
Assignee:
OJI HOLDINGS CORP (JP)
International Classes:
C08B37/00; A61K31/7024; A61K31/737; A61P9/00; A61P13/10; A61P19/00; A61P19/02; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07H11/00
Domestic Patent References:
| WO2014114723A1 | 2014-07-31 | |||
| WO2013186857A1 | 2013-12-19 | |||
| WO2010000013A1 | 2010-01-07 | |||
| WO2014114723A1 | 2014-07-31 |
Foreign References:
| JPS6063203A | 1985-04-11 | |||
| JP6225321B1 | 2017-11-08 | |||
| JPS61197601A | 1986-09-01 | |||
| JP2013177433A | 2013-09-09 | |||
| JP2015038061A | 2015-02-26 | |||
| JPH0320225A | 1991-01-29 | |||
| JP2009532467A | 2009-09-10 | |||
| JPS61197601A | 1986-09-01 | |||
| JP2003183303A | 2003-07-03 |
Other References:
GONZALEZ ET AL., BIOL. PHARM. BULL., vol. 24, no. 2, 2001, pages 151 - 154
S. SWAIN ET AL., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 698, 1993, pages 63 - 67
G. ZUGMAIER ET AL., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 886, 1999, pages 243 - 248
G. ZUGMAIER ET AL., JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 84, no. 22, 1992, pages 1716 - 1724
S. SWAIN ET AL., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 698, 1993, pages 63 - 67
G. ZUGMAIER ET AL., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 886, 1999, pages 243 - 248
G. ZUGMAIER ET AL., JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 84, no. 22, 1992, pages 1716 - 1724
Attorney, Agent or Firm:
SIKS & CO. (JP)
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