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Title:
PEPTIDE ANTIBIOTIC COMPLEXES AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/067498
Kind Code:
A3
Abstract:
Provided herein are compounds that form covalent bonds with peptidases, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SPase), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Inventors:
SMITH, Peter Andrew (Inc.1 DNA Wa, South San Francisco California, 94080, US)
MURRAY, Jeremy Mark (Inc.1 DNA Wa, South San Francisco California, 94080, US)
KOEHLER, Michael Friedrich Thomas (Inc.1 DNA Wa, South San Francisco California, 94080, US)
HEISE, Christopher E. (Inc.1 DNA Wa, South San Francisco California, 94080, US)
Application Number:
US2018/052791
Publication Date:
May 16, 2019
Filing Date:
September 26, 2018
Export Citation:
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Assignee:
GENENTECH, INC. (1 DNA Way, South San Francisco, California, 94080, US)
International Classes:
C07K14/81; A61K38/07; A61K38/55; C07K5/02; C07K5/10; C07K5/11
Domestic Patent References:
WO2017084629A12017-05-26
Foreign References:
CN103788176A2014-05-14
Other References:
LIU JIAN ET AL: "Efforts toward broadening the spectrum of arylomycin antibiotic activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 20, 14 August 2013 (2013-08-14), pages 5654 - 5659, XP028731070, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2013.08.026
J. HIROSHI MORISAKI ET AL: "A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase", MBIO, vol. 7, no. 5, 2 November 2016 (2016-11-02), XP055577864, DOI: 10.1128/mBio.00412-16
SMITH PETER A ET AL: "Optimized arylomycins are a new class of Gram-negative antibiotics", NATURE, MACMILLAN JOURNALS LTD, LONDON, vol. 561, no. 7722, 12 September 2018 (2018-09-12), pages 189 - 194, XP036608977, ISSN: 0028-0836, [retrieved on 20180912], DOI: 10.1038/S41586-018-0483-6
Attorney, Agent or Firm:
HALL, Robert C. et al. (Inc.1 DNA Way,Mail Stop 4, South San Francisco California, 94080, US)
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