Title:
PEPTIDE FOR CANCER TREATMENT AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2017/126461
Kind Code:
A1
Abstract:
The present invention provides a peptide comprising a structure in which a stapling structure is substituted for a portion of the dominant negative peptide of BIG3 that inhibits the interaction between BIG3 and PHB2. The peptide according to the present invention has an excellent cell proliferation inhibitory action. In addition, this cell proliferation inhibitory action lasts for a longer period of time than with a peptide lacking a stapling structure. Due to this, the peptide according to the present invention is characteristically suitable for clinical applications in cancer treatment.
Inventors:
KATAGIRI TOYOMASA (JP)
MIYAMOTO TAKASHI (JP)
HAYASHI RIE (JP)
MIYAMOTO TAKASHI (JP)
HAYASHI RIE (JP)
Application Number:
PCT/JP2017/001187
Publication Date:
July 27, 2017
Filing Date:
January 16, 2017
Export Citation:
Assignee:
UNIV TOKUSHIMA (JP)
ONCOTHERAPY SCIENCE INC (JP)
ONCOTHERAPY SCIENCE INC (JP)
International Classes:
C07K7/00; A61K38/00; A61P35/00
Domestic Patent References:
| WO2013018690A1 | 2013-02-07 |
Other References:
YOSHIMARU T. ET AL.: "Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells", NATURE COMMUN., vol. 4, 20 September 2013 (2013-09-20), pages 1 - 13, XP055402942
LAU Y. H. ET AL.: "Peptide stapling techniques based on different macrocyclisation chemistries", CHEMICAL SOCIETY REVIEWS, vol. 44, no. 1, 7 January 2015 (2015-01-07), pages 91 - 102, XP055387213
AIHARA K. ET AL.: "Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reaction", TETRAHEDRON, vol. 71, no. 24, June 2015 (2015-06-01), pages 4183 - 4191, XP029155365
BLACKWELL H. E. ET AL.: "Highly efficient synthesis of covalently cross-linked peptide helices by ring-closing metathesis", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 37, no. 23, 17 December 1998 (1998-12-17), pages 3281 - 3284, XP055537101
TETSURO YOSHIMARU ET AL.: "Hormone Ryoho Taisei Nyugan Chiryo o Mokuteki to shita Bunshinai Kakyogata BIG3-PHB3 Sogo Sayo Sogai Peptide no Kaihatsu", THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 10 May 2016 (2016-05-10), pages 102, XP009513790
See also references of EP 3406626A4
LAU Y. H. ET AL.: "Peptide stapling techniques based on different macrocyclisation chemistries", CHEMICAL SOCIETY REVIEWS, vol. 44, no. 1, 7 January 2015 (2015-01-07), pages 91 - 102, XP055387213
AIHARA K. ET AL.: "Synthesis of lactam-bridged cyclic peptides using sequential olefin metathesis and diimide reduction reaction", TETRAHEDRON, vol. 71, no. 24, June 2015 (2015-06-01), pages 4183 - 4191, XP029155365
BLACKWELL H. E. ET AL.: "Highly efficient synthesis of covalently cross-linked peptide helices by ring-closing metathesis", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 37, no. 23, 17 December 1998 (1998-12-17), pages 3281 - 3284, XP055537101
TETSURO YOSHIMARU ET AL.: "Hormone Ryoho Taisei Nyugan Chiryo o Mokuteki to shita Bunshinai Kakyogata BIG3-PHB3 Sogo Sayo Sogai Peptide no Kaihatsu", THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 10 May 2016 (2016-05-10), pages 102, XP009513790
See also references of EP 3406626A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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