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Patent Searching and Data


Title:
PEPTIDE CAPABLE OF IMPROVING COGNITIVE FUNCTION
Document Type and Number:
WIPO Patent Application WO/2019/168149
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a peptide having an excellent effect to prevent the deterioration in a cognitive function and to improve a cognitive function; and a use of the peptide. In the present invention, a tripeptide represented by the formula: Tyr-Leu-Gly is used as an active ingredient of a composition for the improvement in a cognitive function or a composition for the enhancement of the expression of a brain-derived neurotrophic factor in the hippocampus. These compositions include a food composition, a food additive composition and a pharmaceutical composition.

Inventors:
OHINATA KOUSAKU (JP)
NAGAI AKITOSHI (JP)
KOZUTSUMI DAISUKE (JP)
Application Number:
JP2019/008055
Publication Date:
September 06, 2019
Filing Date:
March 01, 2019
Export Citation:
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Assignee:
THE FOOD SCIENCE INST FOUNDATION (JP)
International Classes:
A61K38/06; A23L33/18; A61K35/20; A61P25/28; C07K5/087
Domestic Patent References:
WO2013034982A22013-03-14
Foreign References:
JP2017213197A2017-12-07
JP2012508254A2012-04-05
JP2014189549A2014-10-06
JP2012012358A2012-01-19
JP2017008104A2017-01-12
JP2015154773A2015-08-27
Other References:
UCHIDA, TOMOKI ET AL.: "Hippocampal neurogenesis effect and antidepressant effects of milk-derived peptide Tyr-Leu-Gly", LECTURE ABSTRACTS OF THE 2014 CONFERENCE OF JSBBA, 5 March 2014 (2014-03-05)
NAGAI, AKITOSHI ET AL.: "Milk-derived peptides improve cognitive decline associated with the intake of high-fat foods", LECTURE ABSTRACTS OF THE 2018 CONFERENCE OF JSBBA, 5 March 2018 (2018-03-05)
MIZUSHIGE, TAKAFUMI ET AL.: "Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine as-casein", FASEB J, vol. 27, no. 7, 2013, pages 2911 - 2917
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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