Title:
PEPTIDE CAPABLE OF INHIBITING MATE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2014/021389
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a peptide which can inhibit the multidrug efflux transport activity of MATE protein. The present invention provides a peptide which can inhibit the multidrug efflux transport activity of MATE protein and has a cyclic moiety composed of 3 to 15 amino acid residues and a tail composed of one or more amino acid residues.
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Inventors:
SUGA HIROAKI (JP)
NUREKI OSAMU (JP)
HIPOLITO CHRISTOPHER J (JP)
TANAKA YOSHIKI (JP)
NUREKI OSAMU (JP)
HIPOLITO CHRISTOPHER J (JP)
TANAKA YOSHIKI (JP)
Application Number:
PCT/JP2013/070779
Publication Date:
February 06, 2014
Filing Date:
July 31, 2013
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N15/09; A61K38/00; A61P31/04; A61P35/00; A61P43/00; C07K5/12; C07K7/52; C07K7/64
Other References:
KUSUHARA H,. ET AL.: "Effects of a MATE Protein Inhibitor, Pyrimethamine, on the Renal Elimination of Metformin at Oral Microdose and at Therapeutic Dose in Healthy Subjects.", CLIN. PHARMACOL. THER., vol. 89, no. 6, 2011, pages 837 - 844
ITO S. ET AL.: "Potent and Specific Inhibition of mMatel-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine.", J. PHARMACOL. EXP. THER., vol. 333, no. 1, 2010, pages 341 - 350
YAMAGISHI Y. ET AL.: "Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome- Expressed De Novo Library.", CHEM. BIOL., vol. 18, 2011, pages 1562 - 1570
HAYASHI Y. ET AL.: "In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors.", ACS CHEM. BIOL., vol. 7, January 2012 (2012-01-01), pages 607 - 613
MORIMOTO J. ET AL.: "Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2.", ANGEW. CHEM., vol. 124, April 2012 (2012-04-01), pages 3479 - 3483
ATSUSHI YAMAGUCHI ET AL.: "Drug discovery of non-standard peptide with genetic code reprogramming", DRUG DELIVERY SYSTEM, vol. 26, no. 6, 2011, pages 584 - 592
TANAKA Y. ET AL.: "Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.", NATURE, vol. 496, April 2013 (2013-04-01), pages 247 - 251
ITO S. ET AL.: "Potent and Specific Inhibition of mMatel-Mediated Efflux of Type I Organic Cations in the Liver and Kidney by Pyrimethamine.", J. PHARMACOL. EXP. THER., vol. 333, no. 1, 2010, pages 341 - 350
YAMAGISHI Y. ET AL.: "Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome- Expressed De Novo Library.", CHEM. BIOL., vol. 18, 2011, pages 1562 - 1570
HAYASHI Y. ET AL.: "In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors.", ACS CHEM. BIOL., vol. 7, January 2012 (2012-01-01), pages 607 - 613
MORIMOTO J. ET AL.: "Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2.", ANGEW. CHEM., vol. 124, April 2012 (2012-04-01), pages 3479 - 3483
ATSUSHI YAMAGUCHI ET AL.: "Drug discovery of non-standard peptide with genetic code reprogramming", DRUG DELIVERY SYSTEM, vol. 26, no. 6, 2011, pages 584 - 592
TANAKA Y. ET AL.: "Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.", NATURE, vol. 496, April 2013 (2013-04-01), pages 247 - 251
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
Yoshiyuki Inaba (JP)
Yoshiyuki Inaba (JP)
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