Title:
PEPTIDE CENTRIC ANALYSES
Document Type and Number:
WIPO Patent Application WO/2023/133536
Kind Code:
A3
Abstract:
The present disclosure describes a method for assaying a biological sample. In some cases, the method comprises assaying a set of nucleic acids from the biological sample to obtain genotypic information of the biological sample. In some cases, the method comprises generating, based at least in part on the genotypic information, a set of expressible proteoforms that can be expressed from the set of nucleic acids. In some cases, the method comprises assaying a set of polyamino acids from the biological sample to generate proteomic information of the biological sample, wherein the proteomic information comprises a set of identifications for the set of polyamino acids. In some cases, the method comprises mapping the set of identifications to the set of expressible proteoforms, thereby determining a set of expressed proteoforms in the biological sample.
Inventors:
DONOVAN MARGARET (US)
HUANG YINGXIANG (US)
WANG JIAN (US)
KIM SANGTAE (US)
BLUME JOHN (US)
SIDDIQUI ASIM SAROSH (US)
HORNBURG DANIEL (US)
ROSHDIFERDOSI SHADI (US)
ZAMANIGHOMI MAHDI (US)
GUTURU HARENDRA (US)
HUANG YINGXIANG (US)
WANG JIAN (US)
KIM SANGTAE (US)
BLUME JOHN (US)
SIDDIQUI ASIM SAROSH (US)
HORNBURG DANIEL (US)
ROSHDIFERDOSI SHADI (US)
ZAMANIGHOMI MAHDI (US)
GUTURU HARENDRA (US)
Application Number:
PCT/US2023/060271
Publication Date:
September 28, 2023
Filing Date:
January 06, 2023
Export Citation:
Assignee:
SEER INC (US)
International Classes:
G16B25/10; G01N33/551; A61B5/00; G16B40/00; G16H50/20
Foreign References:
| US20200348307A1 | 2020-11-05 | |||
| US20180284125A1 | 2018-10-04 | |||
| US20030055237A1 | 2003-03-20 |
Other References:
SEARLE BRIAN C., SWEARINGEN KRISTIAN E., BARNES CHRISTOPHER A., SCHMIDT TOBIAS, GESSULAT SIEGFRIED, KÜSTER BERNHARD, WILHELM MATHI: "Generating high quality libraries for DIA MS with empirically corrected peptide predictions", NATURE COMMUNICATIONS, vol. 11, no. 1, pages 1 - 10, XP093096410, DOI: 10.1038/s41467-020-15346-1
Attorney, Agent or Firm:
GIL, Phwey (US)
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