PEPTIDE COMPOSITIONS AND METHODS FOR INHIBITING HERPESVIRUS INFECTION

Title:

PEPTIDE COMPOSITIONS AND METHODS FOR INHIBITING HERPESVIRUS INFECTION

Document Type and Number:

WIPO Patent Application WO/2011/053798

Kind Code:

A3

Abstract:

The present invention provides an isolated peptide having an amino acid residue sequence that comprises at least one human cytomegalovirus glycoprotein B (HCMV-gB) sequence segment, each HCMV-gB sequence segment consisting of at least 8 and not more than 60 consecutive amino acid residues from residues 146 to 315, residues 476 to 494 of SEQ ID NO: 1, or from a sequence variant of residues 146 to 315 or 476 to 494 of SEQ ID NO: 1 that has at least 70 % sequence identity thereto. The peptides of the invention are useful for treating, preventing, or inhibiting a herpesvirus (e.g., Herpes Simplex Virus- 1, Human Cytomegalovirus, and the like) infection in a subject.

Inventors:

MELNIK LILIA I (US)
GARRY ROBERT F (US)
MORRIS CINDY A (US)

Application Number:

PCT/US2010/054743

Publication Date:

September 22, 2011

Filing Date:

October 29, 2010

Export Citation:

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Assignee:

UNIV TULANE (US)
MELNIK LILIA I (US)
GARRY ROBERT F (US)
MORRIS CINDY A (US)

International Classes:

C07K14/045; A61K39/245; A61P31/22

Domestic Patent References:

WO1999001464A1

1999-01-14

Foreign References:

US20040091852A1	2004-05-13
US5831001A	1998-11-03
US20090181889A1	2009-07-16
US5514577A	1996-05-07

Other References: