Title:
PEPTIDE FRAGMENTS HAVING CELL DEATH INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2000/031131
Kind Code:
A1
Abstract:
Peptide fragment(s) having an activity of inhibiting cell death which contain the amino acid sequence consisting of 103 amino acid residues in the C-terminal side of selenoprotein P, an amino acid sequence derived from the above amino acid sequence by deletion, substitution or addition of one or several amino acids therein, or a partial sequence of either of the above amino acid sequences; remedies containing the above peptide fragment(s); antibodies against the above peptide fragment(s); and a method for screening a cell death inhibitory activity with the use of the above peptide fragment(s). Preferable examples of the above peptide fragment(s) are those containing the amino acid sequence(s) represented by SEQ ID NO:1 and/or 2 or partial sequences thereof.
Inventors:
HIRASHIMA MASAKI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
Application Number:
PCT/JP1999/006322
Publication Date:
June 02, 2000
Filing Date:
November 12, 1999
Export Citation:
Assignee:
CHEMO SERO THERAPEUT RES INST (JP)
HIRASHIMA MASAKI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
HIRASHIMA MASAKI (JP)
MAEDA HIROAKI (JP)
NOZAKI CHIKATERU (JP)
International Classes:
C07K14/47; A61K38/00; (IPC1-7): C07K14/47; A61K38/17; C12N5/06; C07K16/18
Other References:
HILL K.E. ET AL.: "Conserved nucleotide sequence in the open reading frame and 3' untranslated region of selenoprotein P mTNA", PROC. NATL. ACAD. SCI. USA,, vol. 90, no. 2, 1993, pages 537 - 541, XP002924556
AKESSON B. ET AL.: "Purification of selenoprotein P from human plasma", BIOCHIM. BIOPHYS. ACTA,, vol. 1204, no. 2, 1994, pages 243 - 249, XP002924557
HILL K.E. ET AL.: "Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects", J. NUTR.,, vol. 126, no. 1, 1996, pages 138 - 145, XP002924558
PERSSON-MOSCHOS M. ET AL.: "Selenoprotein P in serum as a biochemical marker of selenium status", ANALYST.,, vol. 120, no. 3, 1995, pages 833 - 836, XP002924559
ARTEEL G.E. ET AL.: "Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration", BIOL. CHEM.,, vol. 379, no. 8-9, August 1998 (1998-08-01) - September 1998 (1998-09-01), pages 1201 - 1205, XP002924560
ZURBONSEN K. ET AL.: "Apoptotic effects of imidazo (1,2-a)pyrazine Derivatives in the human Dami cell line", EUR. J. PHARMACOL.,, vol. 320, no. 2-3, September 1997 (1997-09-01), pages 215 - 221, XP002924561
THOMPSON C. B., SCIENCE, vol. 267, 1995, pages 1456 - 1462
HILL K. E.; BURK R. F., BIOMED. ENVIRON. SCI., vol. 10, 1997, pages 198 - 208
GREENBERG S. M. ET AL., BLOOD, vol. 72, 1988, pages 1968 - 1977
AKESSON B. ET AL.: "Purification of selenoprotein P from human plasma", BIOCHIM. BIOPHYS. ACTA,, vol. 1204, no. 2, 1994, pages 243 - 249, XP002924557
HILL K.E. ET AL.: "Selenoprotein P concentration in plasma is an index of selenium status in selenium-deficient and selenium-supplemented Chinese subjects", J. NUTR.,, vol. 126, no. 1, 1996, pages 138 - 145, XP002924558
PERSSON-MOSCHOS M. ET AL.: "Selenoprotein P in serum as a biochemical marker of selenium status", ANALYST.,, vol. 120, no. 3, 1995, pages 833 - 836, XP002924559
ARTEEL G.E. ET AL.: "Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration", BIOL. CHEM.,, vol. 379, no. 8-9, August 1998 (1998-08-01) - September 1998 (1998-09-01), pages 1201 - 1205, XP002924560
ZURBONSEN K. ET AL.: "Apoptotic effects of imidazo (1,2-a)pyrazine Derivatives in the human Dami cell line", EUR. J. PHARMACOL.,, vol. 320, no. 2-3, September 1997 (1997-09-01), pages 215 - 221, XP002924561
THOMPSON C. B., SCIENCE, vol. 267, 1995, pages 1456 - 1462
HILL K. E.; BURK R. F., BIOMED. ENVIRON. SCI., vol. 10, 1997, pages 198 - 208
GREENBERG S. M. ET AL., BLOOD, vol. 72, 1988, pages 1968 - 1977
Attorney, Agent or Firm:
Aoyama, Tamotsu (3-7 Shiromi 1-chome Chuo-ku Osaka-shi, Osaka, JP)
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