Title:
PEPTIDE HAVING ANTICANCER ACTIVITY, AND PHARMACEUTICAL COMPOSITION AND DIETARY SUPPLEMENT COMPOSITION FOR PREVENTING AND TREATING CANCER, BOTH OF WHICH CONTAIN SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2016/159627
Kind Code:
A1
Abstract:
The present invention relates to a peptide having an anticancer activity, and a pharmaceutical composition and a dietary supplement composition for preventing and treating cancer, both of which contain the same as an active ingredient and, more specifically, to a peptide binding to transcription factor CP2c, having an activity of preventing and treating cancer and represented by SEQ ID NO: 1, and a pharmaceutical composition and a dietary supplement composition for preventing and treating cancer, both of which contain the same as an active ingredient.
Asn-Tyr-Pro-Gln-Arg-Pro
When cancer cells are treated with the peptide and the pharmaceutical composition containing the same, according to the present invention, the peptide can specifically bind to CP2c by passing, with very high stability, through the cell membrane and can inhibit the DNA binding ability of CP2c, thereby disturbing CP2c-mediated cancer cell-specific transcriptional activity through the inhibition of CP2c activity, and thus the present invention can be effectively used for specifically treating only cancer cells, and can be utilized for cancer prevention and as a dietary supplement additive therefor.
Inventors:
KIM CHUL GEUN (KR)
KIM MIN YOUNG (KR)
KIM CHAN GIL (KR)
KANG HO CHUL (KR)
CHAE JI HYUNG (KR)
LEE SU JAE (KR)
BACK EUN JUNG (KR)
YUN CHAE OK (KR)
LEE JIN WON (KR)
LIM YOUNG SU (KR)
CHOI JE MIN (KR)
HA DAE HYUN (KR)
WON HYUNG SIK (KR)
SON SEUNG HAN (KR)
KIM MIN YOUNG (KR)
KIM CHAN GIL (KR)
KANG HO CHUL (KR)
CHAE JI HYUNG (KR)
LEE SU JAE (KR)
BACK EUN JUNG (KR)
YUN CHAE OK (KR)
LEE JIN WON (KR)
LIM YOUNG SU (KR)
CHOI JE MIN (KR)
HA DAE HYUN (KR)
WON HYUNG SIK (KR)
SON SEUNG HAN (KR)
Application Number:
PCT/KR2016/003179
Publication Date:
October 06, 2016
Filing Date:
March 29, 2016
Export Citation:
Assignee:
IUCF-HYU (INDUSTRY-UNIVERSITY COOP FOUND HANYANG UNIVERSITY) (KR)
International Classes:
A61K38/08; C07K7/06
Foreign References:
| US20130028899A1 | 2013-01-31 |
Other References:
KIM, MIN YOUNG ET AL.: "A DNA Immunoprecipitation Assay used in Quantitative Detection of In Vitro DNA-protein Complex Binding", ANALYTICAL BIOCHEMISTRY, vol. 441, no. 2, 16 July 2013 (2013-07-16), pages 147 - 151, XP028711282
KANG, HO CHUL ET AL.: "Identification and Characterization of Four Novel Peptide Motifs that Recognize Distinct Regions of the Transcription Factor CP2", THE FEBS JOURNAL, vol. 272, no. 5, 2005, pages 1265 - 1277, XP055316726
XU, XIAO ET AL.: "Characterization of Genome-Wide TFCP2 Targets in Hepatocellular Carcinoma: Implication of Targets FN1 and TJP1 in Metastasis", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 34, no. 6, 22 January 2015 (2015-01-22), pages 1 - 11, XP021210361
SANTHEKADUR, PRASANNA K ET AL.: "The Transcription Factor LSF: A Novel Oncogene for Hepatocellular Carcinoma", AMERICAN JOURNAL OF CANCER RESEARCH, vol. 2, no. 3, 2012, pages 269 - 285, XP055316731
KANG, HO CHUL ET AL.: "Identification and Characterization of Four Novel Peptide Motifs that Recognize Distinct Regions of the Transcription Factor CP2", THE FEBS JOURNAL, vol. 272, no. 5, 2005, pages 1265 - 1277, XP055316726
XU, XIAO ET AL.: "Characterization of Genome-Wide TFCP2 Targets in Hepatocellular Carcinoma: Implication of Targets FN1 and TJP1 in Metastasis", JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, vol. 34, no. 6, 22 January 2015 (2015-01-22), pages 1 - 11, XP021210361
SANTHEKADUR, PRASANNA K ET AL.: "The Transcription Factor LSF: A Novel Oncogene for Hepatocellular Carcinoma", AMERICAN JOURNAL OF CANCER RESEARCH, vol. 2, no. 3, 2012, pages 269 - 285, XP055316731
Attorney, Agent or Firm:
JUNG, Eun Youl (KR)
정은열 (KR)
정은열 (KR)
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