Title:
PEPTIDE HAVING OSTEOBLAST DIFFERENTIATION AND ANGIOGENESIS-PROMOTING ACTIVITY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/175532
Kind Code:
A1
Abstract:
The present invention relates to a protein effective for osteoblast differentiation and angiogenesis promotion and, more specifically, to a peptide and a use thereof, wherein the peptide comprises 15 amino acids which are synthesized on the basis of some sites of a stromal cell derived factor (SDF-1) delta representing angiogenesis-promoting activity and osteoblast differentiation or osteogenesis activity.
Inventors:
YOON TAEK RIM (KR)
KIM HYUNG KEUN (KR)
SEON JONG KEUN (KR)
KIM JI HYUN (KR)
KANG JU YEON (KR)
KIM HYUNG KEUN (KR)
SEON JONG KEUN (KR)
KIM JI HYUN (KR)
KANG JU YEON (KR)
Application Number:
PCT/KR2016/004346
Publication Date:
November 03, 2016
Filing Date:
April 26, 2016
Export Citation:
Assignee:
NAT UNIV CHONNAM IND FOUND (KR)
CHONNAM NAT UNIV HOSPITAL (KR)
CHONNAM NAT UNIV HOSPITAL (KR)
International Classes:
A61K38/10; C07K7/08; C07K14/51; C12N5/00
Foreign References:
| US20140288010A1 | 2014-09-25 | |||
| US20110020375A1 | 2011-01-27 | |||
| US20110207166A1 | 2011-08-25 |
Other References:
MISHIMA, SEIJI ET AL.: "Effective Ex Vivo Expansion of Hematopoietic Stem Cells using Osteoblast-differentiated Mesenchymal Stem Cells is CXCL12 Dependent", EUROPEAN JOURNAL OF HAEMATOLOGY, vol. 84, no. 6, 2010, pages 538 - 546, XP055326592
LISIGNOLI, GINA ET AL.: "CXCL12 (SDF-1) and CXCL13 (BCA-1) Chemokines Significantly induce Proliferation and Collagen Type I Expression in Osteoblasts from Osteoarthritis Patients", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 206, no. 1, 2006, pages 78 - 85, XP055326596
See also references of EP 3290435A4
LISIGNOLI, GINA ET AL.: "CXCL12 (SDF-1) and CXCL13 (BCA-1) Chemokines Significantly induce Proliferation and Collagen Type I Expression in Osteoblasts from Osteoarthritis Patients", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 206, no. 1, 2006, pages 78 - 85, XP055326596
See also references of EP 3290435A4
Attorney, Agent or Firm:
IAM PATENT & LAW FIRM (KR)
특허법인 아이엠 (KR)
특허법인 아이엠 (KR)
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