Title:
PEPTIDE HAVING OSTEOBLAST PROLIFERATION-PROMOTING ACTIVITY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/129726
Kind Code:
A1
Abstract:
In order to provide a novel peptide that has both an osteogenesis-promoting effect and a chondrocyte proliferation-promoting effect, the present invention provides a peptide or a derivative or salt thereof, wherein the peptide has amino acid sequence (a), (b), or (c), 100 or fewer of amino acid residues, and osteoblast proliferation-promoting activity.
(a) Val-Asn-Pro-Glu-Ser-Glu-Glu-Glu-Asp-Glu-Ser-Ser-Pro-Tyr-Glu (sequence No. 1). (b) Amino acid sequence having conservative substitution or deletion of 1 to 3 amino acids in the amino acid sequence (a). (c) Amino acid sequence formed from at least four linked amino acids in the amino acid sequence (a) or (b).
Inventors:
YAMAZAKI CHIHIRO (JP)
AN JI-YEONG (JP)
HARADA SEIYU (JP)
WATABE KAZUYA (JP)
KIM MUJO (JP)
AN JI-YEONG (JP)
HARADA SEIYU (JP)
WATABE KAZUYA (JP)
KIM MUJO (JP)
Application Number:
PCT/JP2015/055340
Publication Date:
September 03, 2015
Filing Date:
February 25, 2015
Export Citation:
Assignee:
PHARMA FOODS INT CO LTD (JP)
International Classes:
C12N15/00; A23L1/305; A61K8/64; A61K31/715; A61K38/00; A61P19/00; A61P19/02; A61P19/10; A61P43/00; C07K7/06; C07K7/08; C12N15/09
Domestic Patent References:
| WO2012167370A1 | 2012-12-13 |
Foreign References:
| US5366871A | 1994-11-22 | |||
| JP2006115761A | 2006-05-11 | |||
| JP2009247459A | 2009-10-29 | |||
| JPH0453471A | 1992-02-21 |
Other References:
SHUN-ICHIRO IEMURA: "Isolation and Characterization of Bone Morphogenetic Protein- binding Proteins from the Early Xenopus Embryo", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 38, 1999, pages 26843 - 26849, XP055220139
JESS LIU: "Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models", DEVELOPMENTAL BIOLOGY, vol. 381, 2013, pages 256 - 275, XP028692932
T. SAITO: "Mineral Induction by Immobilized Phosphoproteins", BONE, vol. 21, no. 4, 1997, pages 305 - 311, XP009045360
See also references of EP 3112459A4
JESS LIU: "Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models", DEVELOPMENTAL BIOLOGY, vol. 381, 2013, pages 256 - 275, XP028692932
T. SAITO: "Mineral Induction by Immobilized Phosphoproteins", BONE, vol. 21, no. 4, 1997, pages 305 - 311, XP009045360
See also references of EP 3112459A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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