PEPTIDE INHIBITORS OF AQUAPORIN-4 AND THEIR USE

Title:

PEPTIDE INHIBITORS OF AQUAPORIN-4 AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/2010/073009

Kind Code:

A3

Abstract:

A peptide comprising a unit of formula (I) and having a molecular weight of less than 2000 wherein each X is independently an organic group, e.g. a C1-6 alkyl or C1-6 alkenyl group, preferably -CH2-CH=CH2, or the two X groups taken together can form a covalent or non-covalent link between the two O groups, preferably a C1-10 saturated or unsaturated carbon chain optionally interrupted by one or more heteroatoms selected from O, S, N, P, or Si, especially a C3-I0 carbon chain or one X represents an azido group and the other an C2-6-alkynyl group; both Z's are the same and are O or S; each Y is independently C, CH, CH2, N or NH; R1 is H or C1-6 alkyl; R2 is H or C1-6 alkyl; R5 is a C1-6 alkyl group, preferably isopropyl; or a salt, ester or prodrug thereof.

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Inventors:

JACOBSEN OYVIND (NO)
KLAVENESS JO (NO)
RONGVED PAL (NO)
AMIRY-MOGHADDAM MAHMOOD (NO)
OTTERSEN OLE PETTER (NO)
SHADIDI KATRINE RESE (NO)

Application Number:

PCT/GB2009/002942

Publication Date:

September 10, 2010

Filing Date:

December 22, 2009

Export Citation:

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Assignee:

UNI I OSLO (NO)
JACOBSEN OYVIND (NO)
KLAVENESS JO (NO)
RONGVED PAL (NO)
AMIRY-MOGHADDAM MAHMOOD (NO)
OTTERSEN OLE PETTER (NO)
SHADIDI KATRINE RESE (NO)
CAMPBELL NEIL (GB)

International Classes:

C07K14/705; A61K38/04

Domestic Patent References:

WO2009050498A2	2009-04-23
WO2009039854A2	2009-04-02
WO2007104062A2	2007-09-13
WO2006091734A2	2006-08-31
WO2004092207A2	2004-10-28

Foreign References:

US20070281978A1

2007-12-06

Other References:

O JACOBSEN ET AL.: "Synthesis of cyclic peptide analogues of the 3-10 helical Pro138-Gly144 segment of human aquaporin-4 by olefin metathesi", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 7, no. 8, 21 April 2009 (2009-04-21), Royal Society of Chemistry, pages 1599 - 1611, XP002583767, ISSN: 1477-0520

Attorney, Agent or Firm:

CAMPBELL, Neil (St. Bride's House10 Salisbury Square, London EC4Y 8JD, GB)

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