Title:
PEPTIDE INHIBITORS OF TEAD/YAP-TAZ INTERACTION
Document Type and Number:
WIPO Patent Application WO/2015/063747
Kind Code:
A3
Abstract:
The invention relates to an isolated peptide inhibitor of the interaction between the TEAD and YAP or TAZ proteins and a derived chimeric peptide linked to a cell-penetrating peptide. These peptides which have a cytotoxic activity are useful, in particular for the treatment of hyperproliferative disorders such as cancer.
Inventors:
REBOLLO GARCIA ANGELITA (FR)
NEMATI FARIBA (FR)
DECAUDIN DIDIER (FR)
NEMATI FARIBA (FR)
DECAUDIN DIDIER (FR)
Application Number:
PCT/IB2014/065794
Publication Date:
November 19, 2015
Filing Date:
November 04, 2014
Export Citation:
Assignee:
UNIV PIERRE ET MARIE CURIE PARIS 6 (FR)
INST CURIE (FR)
INST CURIE (FR)
International Classes:
C07K7/00; A61K38/17; C07K14/47; C07K19/00; A61K38/00; C07K14/00
Domestic Patent References:
| WO2013098339A1 | 2013-07-04 | |||
| WO2013098337A1 | 2013-07-04 | |||
| WO2009045179A1 | 2009-04-09 |
Foreign References:
| CN102136042A | 2011-07-27 |
Other References:
DATABASE UniProt [online] 16 October 2013 (2013-10-16), XP002718810, Database accession no. Q15562
B. ZHAO ET AL: "TEAD mediates YAP-dependent gene induction and growth control", GENES & DEVELOPMENT, vol. 22, no. 14, 15 July 2008 (2008-07-15), pages 1962 - 1971, XP055096567, ISSN: 0890-9369, DOI: 10.1101/gad.1664408
H. ZHANG ET AL: "TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 20, 26 March 2009 (2009-03-26), pages 13355 - 13362, XP055096570, ISSN: 0021-9258, DOI: 10.1074/jbc.M900843200
S. W. CHAN ET AL: "TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 21, 26 March 2009 (2009-03-26), pages 14347 - 14358, XP055096565, ISSN: 0021-9258, DOI: 10.1074/jbc.M901568200
Q.-Y. LEI ET AL: "TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway", MOLECULAR AND CELLULAR BIOLOGY, vol. 28, no. 7, 1 April 2008 (2008-04-01), pages 2426 - 2436, XP055020647, ISSN: 0270-7306, DOI: 10.1128/MCB.01874-07
See also references of EP 3066113A2
B. ZHAO ET AL: "TEAD mediates YAP-dependent gene induction and growth control", GENES & DEVELOPMENT, vol. 22, no. 14, 15 July 2008 (2008-07-15), pages 1962 - 1971, XP055096567, ISSN: 0890-9369, DOI: 10.1101/gad.1664408
H. ZHANG ET AL: "TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 20, 26 March 2009 (2009-03-26), pages 13355 - 13362, XP055096570, ISSN: 0021-9258, DOI: 10.1074/jbc.M900843200
S. W. CHAN ET AL: "TEADs Mediate Nuclear Retention of TAZ to Promote Oncogenic Transformation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 21, 26 March 2009 (2009-03-26), pages 14347 - 14358, XP055096565, ISSN: 0021-9258, DOI: 10.1074/jbc.M901568200
Q.-Y. LEI ET AL: "TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway", MOLECULAR AND CELLULAR BIOLOGY, vol. 28, no. 7, 1 April 2008 (2008-04-01), pages 2426 - 2436, XP055020647, ISSN: 0270-7306, DOI: 10.1128/MCB.01874-07
See also references of EP 3066113A2
Attorney, Agent or Firm:
CABINET ORÈS (Paris, FR)
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