PEPTIDE LIBRARY AND USE THEREOF

WIPO Patent Application WO/2014/024914

A1

Provided is a peptide library. A peptide selected from items (1) and (2). A peptide selected from items (i) and (ii): (i) a peptide which contains the amino acid sequence represented by SEQ ID NO: 1 shown in the Sequence Listing and also contains an amino acid sequence encoded by a sequence lying between the 8th nucleotide and the 42nd nucleotide both located in the nucleotide sequence represented by SEQ ID NO: 14 shown in the Sequence Listing and an amino acid sequence encoded by a sequence lying between the 43rd nucleotide and the 93rd nucleotide both located in the nucleotide sequence represented by SEQ ID NO: 14 shown in the Sequence Listing adjacent to the amino terminal and the carboxyl terminal of the amino acid sequence represented by SEQ ID NO: 1, respectively; (ii) a peptide which has an amino acid sequence that is produced by substituting one to five amino acid residues other than an amino acid residue Xaa, which are located in a sequence lying between the 1st amino acid residue and the 12th amino acid residue as numbered from the amino terminal in the amino acid sequence represented by SEQ ID NO: 1 contained in the amino acid sequence for the peptide (i), by a conservative amino acid residue or conservative amino acid residues, deleting the one to five amino acid residues, adding a conservative amino acid residue or conservative amino acid residues to the one to five amino acid residues or inserting a conservative amino acid residue or conservative amino acid residues into the one to five amino acid residues.

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NISHIMIYA DAISUKE (JP)
HASHIMOTO RYUJI (JP)

PCT/JP2013/071345

February 13, 2014

August 07, 2013

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DAIICHI SANKYO CO LTD (JP)

C12N15/00; C07K7/08; C07K14/81; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/37; C40B40/08; C40B40/10

WO2004100988A1

2004-11-25

JP2008545399A	2008-12-18
JP2008260770A	2008-10-30
JP2011511766A	2011-04-14
US20080020394A1	2008-01-24
JP2007524348A	2007-08-30

DATABASE UNIPROT [online] 19 October 2011 (2011-10-19), XP003034303, Database accession no. G1RC24_NOMLE
DATABASE UNIPROT [online] 7 February 2006 (2006-02-07), XP003034304, Database accession no. Q2TBS5_BOVIN
DATABASE UNIPROT [online] 1 February 1994 (1994-02-01), XP003034305, Database accession no. P34953
CHEN T; LEE TR; LIANG WG; CHANG WS; LYU PC.: "Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor", PROTEINS, vol. 77, no. 1, 2009, pages 209 - 19
JAMES D. MARKS; HENNIE R. HOOGENBOOM; TIMOTHY P. BONNERT; JOHN MCCAFFERTY; ANDREW D. GRIFFITHS; GREG WINTER: "By-passing immunization: Human antibodies from V-gene libraries displayed on phage", J MOL BIOL., vol. 222, no. 3, 1991, pages 581 - 97
SKERRA A.: "Alternative non-antibody scaffolds for molecular recognition", CURR OPIN BIOTECHNOL., vol. 18, 2007, pages 295 - 304
L. LEHNINGER: "Biochemistry", 1975, WORTH PUBLISHER, pages: 73 - 75
"Fmoc solid phase peptide synthesis: a practical approach", 2000, OXFORD UNIVERSITY PRESS
GLUZMAN, Y., CELL, vol. 23, 1981, pages 175 - 182
URLAUB, G.; CHASIN, L. A., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4126 - 4220
KEEFE, A.D; SZOSTAK, J.W., NATURE, vol. 410, 2001, pages 715 - 718
YAMAGUCHI, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 37, no. 16, 2009, pages 1 - 13
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 489
See also references of EP 2883954A4

ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)

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