Title:
PEPTIDE MODULATORS OF TUMOUR SPECIFIC PYRUVATE KINASE SUBTYPE M2 (M2-PK)
Document Type and Number:
WIPO Patent Application WO2004016646
Kind Code:
A3
Abstract:
The present invention relates to (a) peptide(s) capable of specifically interacting with pyruvate kinase subtype M2 (M2-PK), wherein said peptide(s) comprise(s) (an) amino acid sequence(s) as disclosed herein. Furthermore, the invention provides for nucleic acid molecule(s) comprising nucleotide sequence(s) encoding said peptide(s), for vectors comprising said nucleic acid molecule(s). In addition, pharmaceutical and diagnostic compositions are disclosed which comprise the peptide(s) of the invention. The invention also relates to specific uses of the peptide(s) of the invention in preparation of pharmaceutical compositions for the treatment or prevention of, inter alia, proliferative and/or tumorous diseases.
Inventors:
SPODEN GILLES (AT)
ZWERSCHKE WERNER PAUL (AT)
JANSEN-DUERR HENDRIK PIDDER (AT)
FITZKY BARBARA (AT)
ZWERSCHKE WERNER PAUL (AT)
JANSEN-DUERR HENDRIK PIDDER (AT)
FITZKY BARBARA (AT)
Application Number:
PCT/EP2003/008901
Publication Date:
December 16, 2004
Filing Date:
August 11, 2003
Export Citation:
Assignee:
AMYNON BIO TECH GMBH (AT)
SPODEN GILLES (AT)
ZWERSCHKE WERNER PAUL (AT)
JANSEN-DUERR HENDRIK PIDDER (AT)
FITZKY BARBARA (AT)
SPODEN GILLES (AT)
ZWERSCHKE WERNER PAUL (AT)
JANSEN-DUERR HENDRIK PIDDER (AT)
FITZKY BARBARA (AT)
International Classes:
C12N9/12; A61K38/00; (IPC1-7): C12N9/12; C12N15/54; C12N15/63; C12Q1/68
Domestic Patent References:
| WO1998002539A1 | 1998-01-22 | |||
| WO2002095063A1 | 2002-11-28 | |||
| WO2002072077A2 | 2002-09-19 |
Foreign References:
| DE10029131A1 | 2002-01-03 | |||
| US6358683B1 | 2002-03-19 | |||
| DE3838900A1 | 1990-05-23 |
Other References:
ZWERSCHKE W ET AL: "IDENTIFICATION OF DOMAINS REQUIRED FOR TRANSCRIPTIONAL ACTIVATION AND PROTEIN DIMERIZATION IN THE HUMAN PAPILLOMAVIRUS TYPE-16 E7 PROTEIN", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 12, 4 January 1996 (1996-01-04), pages 213 - 220, XP002060202, ISSN: 0950-9232
COLAS P ET AL: "GENETIC SELECTION OF PEPTIDE APTAMERS THAT RECOGNIZE AND INHIBIT CYCLIN-DEPENDENT KINASE 2", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 380, 11 April 1996 (1996-04-11), pages 548 - 550, XP000904376, ISSN: 0028-0836
MAZUREK SYBILLE ET AL: "Metabolic cooperation between different oncogenes during cell transformation: Interaction between activated ras and HPV-16 E7", ONCOGENE, vol. 20, no. 47, 18 October 2001 (2001-10-18), pages 6891 - 6898, XP002270961, ISSN: 0950-9232
DATABASE EMBL [online] EMBL; 17 October 2001 (2001-10-17), PENN SG. ET AL: "Peptide #9124 encoded by probe for measuring placental gene expression", XP002282731, retrieved from EBI Database accession no. AAM35087
DATABASE EMBL [online] EMBL; 5 November 2001 (2001-11-05), PENN SG. ET AL.: "Human brain expressed single exon probe encoded protein SEQ ID NO: 34272.", XP002282732, retrieved from EBI Database accession no. AAM62167
COLAS P ET AL: "GENETIC SELECTION OF PEPTIDE APTAMERS THAT RECOGNIZE AND INHIBIT CYCLIN-DEPENDENT KINASE 2", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 380, 11 April 1996 (1996-04-11), pages 548 - 550, XP000904376, ISSN: 0028-0836
MAZUREK SYBILLE ET AL: "Metabolic cooperation between different oncogenes during cell transformation: Interaction between activated ras and HPV-16 E7", ONCOGENE, vol. 20, no. 47, 18 October 2001 (2001-10-18), pages 6891 - 6898, XP002270961, ISSN: 0950-9232
DATABASE EMBL [online] EMBL; 17 October 2001 (2001-10-17), PENN SG. ET AL: "Peptide #9124 encoded by probe for measuring placental gene expression", XP002282731, retrieved from EBI Database accession no. AAM35087
DATABASE EMBL [online] EMBL; 5 November 2001 (2001-11-05), PENN SG. ET AL.: "Human brain expressed single exon probe encoded protein SEQ ID NO: 34272.", XP002282732, retrieved from EBI Database accession no. AAM62167
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