Title:
PEPTIDE NUCLEIC ACID (PNA) MONOMERS WITH AN ORTHOGONALLY PROTECTED ESTER MOIETY
Document Type and Number:
WIPO Patent Application WO/2018/175927
Kind Code:
A3
Abstract:
This application pertains to orthogonally protected esters of peptide nucleic acid (PNA) monomers, which ester groups can be removed under conditions that permit typical backbone and side chain acid- and base-labile protecting groups to remain substantially intact thereby permitting the high yield of PNA monomer carboxylic acids that are suitable for use in PNA oligomer synthesis. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethyl (TCE), 2,2,2-tribromoethyl (TBE), 2-bromoethyl (2-BE) and 2-iodoethyl groups (2-IE). This invention also pertains to novel methods for the synthesis of Backbone Ester compounds and related Backbone Ester Acid Salts.
Inventors:
COULL JAMES (US)
GILDEA BRIAN (US)
GILDEA BRIAN (US)
Application Number:
PCT/US2018/024087
Publication Date:
November 01, 2018
Filing Date:
March 23, 2018
Export Citation:
Assignee:
TRUCODE GENE REPAIR INC (US)
International Classes:
C07D239/52; A61K31/513; A61K31/522; C07D473/18; C07K14/00
Domestic Patent References:
| WO1993012129A1 | 1993-06-24 | |||
| WO2004024757A2 | 2004-03-25 |
Foreign References:
| KR20170002649A | 2017-01-06 | |||
| US20120065364A2 | 2012-03-15 | |||
| US20110014715A1 | 2011-01-20 | |||
| US6316595B1 | 2001-11-13 |
Other References:
See also references of EP 3601237A4
Attorney, Agent or Firm:
COLLAZO, Diana, M. et al. (US)
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